{"id":"W4407395132","doi":"10.1101/2025.02.11.25322045","title":"Genome-wide association study of susceptibility to acute respiratory distress syndrome","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Respiratory Support and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"National Heart, Lung, and Blood Institute; NIHR Leicester Biomedical Research Centre; Agencia Estatal de Investigación; National Institute for Health and Care Research; Novo Nordisk; European Regional Development Fund; Bayer HealthCare; European Commission; University of Leicester; Instituto de Salud Carlos III; South East Physics Network; Wellcome Trust; GlaxoSmithKline; Asthma and Lung UK; AstraZeneca","keywords":"Acute respiratory distress; Genome-wide association study; Respiratory distress; Medicine; Association (psychology); Genetic association; Respiratory system; Intensive care medicine; Genetics; Psychology; Biology; Psychiatry; Internal medicine; Gene; Single-nucleotide polymorphism; Lung; Genotype; Surgery; Psychotherapist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002728375,0.0004683839,0.0008634305,0.001415555,0.0005280824,0.0009000637,0.0007068753,0.0009059647,0.003865128],"category_scores_gemma":[0.005248644,0.0002631836,0.002184238,0.002924396,0.0004236226,0.0002920999,0.0006743547,0.0009759743,0.000269276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002024405,"about_ca_system_score_gemma":0.0004098102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003131591,"about_ca_topic_score_gemma":0.002761412,"domain_scores_codex":[0.9966035,0.001367255,0.0003746492,0.001141155,0.0003126135,0.0002009128],"domain_scores_gemma":[0.9951261,0.002539489,0.0009524748,0.0005799596,0.0004564949,0.000345549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00109811,0.00005345238,0.9733405,0.0002951964,0.0132515,0.000507882,0.00009083021,0.0003932153,0.004113197,0.0002689563,0.0005234915,0.00606375],"study_design_scores_gemma":[0.0001107091,0.0001338308,0.9924413,0.00006551308,0.003803594,0.0005073707,0.00008419469,0.0007746773,0.0006563331,0.0004359004,0.0009740534,0.00001255348],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979768,0.01225386,0.003249092,0.0005803473,0.0001892186,0.00002807826,0.002463434,0.00006391468,0.001404018],"genre_scores_gemma":[0.9975443,0.0008029279,0.0006168454,0.00008958657,0.00005540363,0.00001744943,0.0006737824,0.000008794783,0.0001908967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003865128,"threshold_uncertainty_score":0.01442921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02868621134041492,"score_gpt":0.3113738832703808,"score_spread":0.2826876719299659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}