{"id":"W4407397393","doi":"10.1039/d4cc06483f","title":"Design of a modular, palladium-catalyzed carbonylative synthesis of pyrido[2,1-α]isoindoles <i>via</i> benzyne 1,3-dipolar cycloaddition","year":2025,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Cyclization and Aryne Chemistry","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Aryne; Cycloaddition; Mesoionic; Palladium; Catalysis; Chemistry; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000153035,0.0002107666,0.0004234619,0.00008889144,0.0001177219,0.00001349842,0.001096132,0.0002184047,0.0001951241],"category_scores_gemma":[0.0007449274,0.0002324768,0.0001713227,0.0004469643,0.0005040091,0.0000856211,0.0004186078,0.0003044143,0.000004485112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008858173,"about_ca_system_score_gemma":0.000119419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000433311,"about_ca_topic_score_gemma":0.000002954832,"domain_scores_codex":[0.9986033,0.00006443416,0.0006739774,0.0002653186,0.0001993092,0.0001936015],"domain_scores_gemma":[0.9962618,0.001202021,0.0003620223,0.001835984,0.000259049,0.00007906411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004023642,0.0003677502,0.0002666912,0.0002650814,0.0001324205,2.576176e-7,0.0001589888,0.00007234861,0.9962941,0.0006055068,0.0002904277,0.00150621],"study_design_scores_gemma":[0.0004384731,0.000002583145,0.00004107882,0.0004299576,0.0001345711,0.000001645538,0.0001680055,0.005611199,0.9908903,0.00154606,0.0005567437,0.0001793337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7375454,0.01118393,0.05038896,0.004044762,0.0001210499,0.0009530805,0.001366172,0.0007236087,0.1936731],"genre_scores_gemma":[0.9928969,0.0004543106,0.005820702,0.00004306265,0.00001810109,0.0001092332,0.0004723497,0.00002364587,0.0001617031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2553515,"threshold_uncertainty_score":0.9480129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01891251739323403,"score_gpt":0.2556311997276142,"score_spread":0.2367186823343802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}