{"id":"W4407405854","doi":"10.1016/j.jare.2025.02.012","title":"Blocking S1P4 signaling attenuates brain injury in mice with ischemic stroke","year":2025,"lang":"en","type":"article","venue":"Journal of Advanced Research","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"National Research Foundation of Korea; Gachon University; National Research Foundation","keywords":"Blocking (statistics); Ischemic stroke; Stroke (engine); Medicine; Computer science; Internal medicine; Computer network; Ischemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001811745,0.0001217001,0.0002401247,0.0004178134,0.00009969892,0.00004301073,0.0003478675,0.000102906,0.000006802898],"category_scores_gemma":[0.0007163313,0.00009801466,0.00007696933,0.0004650196,0.00009681207,0.00001755933,0.0001186979,0.0006400236,0.000001157534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000382297,"about_ca_system_score_gemma":0.0003358624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001060888,"about_ca_topic_score_gemma":0.00001203805,"domain_scores_codex":[0.9984263,0.000169537,0.0003890906,0.0002233869,0.0003930595,0.000398584],"domain_scores_gemma":[0.9989669,0.000143565,0.0001403419,0.0001749048,0.0004923646,0.00008190163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008316391,0.00004856815,0.002462895,0.0000350524,0.00005207254,0.0000179509,0.00007545944,0.002213156,0.986281,0.00002436155,0.001518103,0.006439736],"study_design_scores_gemma":[0.001337951,0.0002825363,0.0004296607,0.0003179622,0.000009283719,0.00002486608,0.0007303157,0.00004213176,0.961167,0.00006964416,0.03548076,0.0001078753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939331,0.003345161,0.0009515987,0.0006030849,0.0001219805,0.0001134429,0.000003398303,0.000002853201,0.000925321],"genre_scores_gemma":[0.9947633,0.0003812178,0.003408494,0.0001776389,0.0003233937,0.000005491159,0.000003105238,0.000017351,0.0009200385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03396266,"threshold_uncertainty_score":0.3996922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01671080065775847,"score_gpt":0.3485947207062748,"score_spread":0.3318839200485163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}