{"id":"W4407409544","doi":"10.1080/08820139.2025.2462536","title":"Variable Lymphocyte Receptor B Technologies – Are They Ready for Prime Time?","year":2025,"lang":"en","type":"review","venue":"Immunological Investigations","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Sick Kids Foundation","keywords":"Receptor; Common variable immunodeficiency; Lymphocyte; Prime (order theory); Immunology; Biology; Computational biology; Genetics; Chemistry; Antibody; Mathematics; Combinatorics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000632019,0.0005866633,0.002232752,0.0005136264,0.0003165875,0.00008180102,0.0007006711,0.001514892,0.002058323],"category_scores_gemma":[0.005268663,0.0004150808,0.0005819441,0.001106706,0.0007285639,0.00008863895,0.0003920679,0.001049779,0.0008343719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008696086,"about_ca_system_score_gemma":0.001764736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002481327,"about_ca_topic_score_gemma":8.244785e-7,"domain_scores_codex":[0.997066,0.0002866831,0.0008546632,0.0007182255,0.0003131852,0.0007612962],"domain_scores_gemma":[0.9958471,0.001977863,0.0003993941,0.001285116,0.0003510227,0.000139526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005762924,0.0002910718,0.000005230002,0.0072923,0.000894324,0.000005157427,0.00002096085,4.389845e-7,0.002016461,0.01101807,0.008268363,0.97013],"study_design_scores_gemma":[0.0005287626,0.0002396391,0.000003000788,0.01134864,0.0009058669,0.0000471344,0.00005029219,0.000007087204,0.000362993,0.003967304,0.9821701,0.0003691492],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000003504327,0.9848388,0.0001510678,0.0009613279,0.0002541711,0.004276137,0.0005252279,0.00105188,0.007937897],"genre_scores_gemma":[7.435272e-7,0.9181936,0.01744374,0.0001154481,0.0001431166,0.003127214,0.001825209,0.00006807016,0.05908281],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9739017,"threshold_uncertainty_score":0.9999436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1231455512549307,"score_gpt":0.3852417675768454,"score_spread":0.2620962163219148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}