{"id":"W4407409544","doi":"10.1080/08820139.2025.2462536","title":"Variable Lymphocyte Receptor B Technologies – Are They Ready for Prime Time?","year":2025,"lang":"en","type":"review","venue":"Immunological Investigations","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Sick Kids Foundation","keywords":"Receptor; Common variable immunodeficiency; Lymphocyte; Prime (order theory); Immunology; Biology; Computational biology; Genetics; Chemistry; Antibody; Mathematics; Combinatorics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005887905,0.000365247,0.001075662,0.001331205,0.0001917183,0.002460382,0.001096496,0.002186462,0.01085973],"category_scores_gemma":[0.009147403,0.0002675754,0.000833197,0.001244286,0.0008313258,0.005408665,0.000689151,0.002244871,0.004752833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007533747,"about_ca_system_score_gemma":0.0019022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005675009,"about_ca_topic_score_gemma":0.0005882967,"domain_scores_codex":[0.9982548,0.0007455155,0.000265981,0.0001301234,0.0004641136,0.0001394512],"domain_scores_gemma":[0.9942525,0.003988292,0.0006822525,0.0001376103,0.0007414197,0.0001979556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005148964,0.00007155488,0.0005048329,0.02904102,0.0001941709,0.0002635777,0.000161402,0.0001270314,0.002133146,0.01550998,0.04103315,0.9104453],"study_design_scores_gemma":[0.00009560341,0.0003075304,0.0005748767,0.01800548,0.0002022558,0.001147116,0.0002861506,0.000043816,0.001109617,0.009264778,0.9689398,0.00002298998],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000562251,0.9893633,0.0006159418,0.005665673,0.001006099,0.00002321197,0.00008352577,0.00001648404,0.002663539],"genre_scores_gemma":[0.006668063,0.9783956,0.001990909,0.008806562,0.001935507,0.00009437768,0.000215947,0.00002368516,0.00186938],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01085973,"threshold_uncertainty_score":0.03632939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1231455512549307,"score_gpt":0.3852417675768454,"score_spread":0.2620962163219148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}