{"id":"W4407417924","doi":"10.1093/ijnp/pyae059.129","title":"ANTI-COMPULSIVE ACTION OF ESCITALOPRAM IN DEER MICE PARALLELS DECREASED PLASMA LIPOPOLYSACCHARIDE AND INCREASED FRONTAL-CORTICAL AND STRIATAL TRYPTOPHAN, BUT NOT SEROTONIN CONCENTRATIONS","year":2025,"lang":"en","type":"article","venue":"The International Journal of Neuropsychopharmacology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North","funders":"","keywords":"Escitalopram; Serotonin; Tryptophan; Lipopolysaccharide; Psychology; Quinolinic acid; Action (physics); Internal medicine; Endocrinology; Citalopram; Neuroscience; Pharmacology; Chemistry; Medicine; Antidepressant; Biochemistry; Receptor; Hippocampus; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001749409,0.0008493889,0.0005094536,0.001104285,0.0002360579,0.0004173265,0.0004017157,0.0007137232,0.002989543],"category_scores_gemma":[0.0001555183,0.0003277992,0.0005146923,0.0002634623,0.000775551,0.0004193096,0.0002495647,0.001997233,0.0007469879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005125099,"about_ca_system_score_gemma":0.0003823047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001165696,"about_ca_topic_score_gemma":0.002151152,"domain_scores_codex":[0.9997426,0.00002623455,0.00002414978,0.00008105794,0.00004443579,0.00008146364],"domain_scores_gemma":[0.9996019,0.00002181219,0.000109415,0.00003616598,0.0000319317,0.0001988228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001131836,0.0004166038,0.001008841,0.00006700482,0.00001571169,0.0001371064,0.00004659302,0.00003367517,0.9953554,0.00005582095,0.0001228953,0.001608545],"study_design_scores_gemma":[0.0003675465,0.009291076,0.04923122,0.00005042953,0.00009942866,0.0012464,0.000386887,0.001096114,0.9353297,0.0002458673,0.002613537,0.00004183371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950125,0.0006906521,0.0009891653,0.0002568339,0.00004841456,0.0000534772,0.001883147,0.0001892288,0.0008766963],"genre_scores_gemma":[0.9861659,0.0009922774,0.003233189,0.0003420363,0.00003350367,0.0003430174,0.001911178,0.00007550127,0.006903511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002989543,"threshold_uncertainty_score":0.010001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02428222207640522,"score_gpt":0.3214582438396153,"score_spread":0.2971760217632101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}