{"id":"W4407418836","doi":"10.1002/alz.14579","title":"SSRIs reduce plasma tau and restore dorsal raphe metabolism in Alzheimer's disease","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health; Alberta Children's Hospital; Hotchkiss Brain Institute; University of Calgary","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; Alberta Children's Hospital Research Institute; National Institutes of Health; Alzheimer Society Research Program; Alzheimer's Society; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Alzheimer's Disease Neuroimaging Initiative; Alzheimer Society; U.S. Department of Defense","keywords":"Serotonergic; Dorsal raphe nucleus; Cognitive decline; Neurodegeneration; Internal medicine; Neuroscience; Raphe nuclei; Psychology; Biomarker; Medicine; Tauopathy; Serotonin; Endocrinology; Disease; Pathology; Dementia; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001119202,0.000265353,0.0003625099,0.0001716427,0.00007660384,0.0001976496,0.0001417747,0.0002158428,0.002100594],"category_scores_gemma":[0.0002549488,0.00007629074,0.0001971799,0.0001177466,0.00008861005,0.0001333292,0.00008221452,0.0002613121,0.0003755355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001595572,"about_ca_system_score_gemma":0.0001424711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006123784,"about_ca_topic_score_gemma":0.001529886,"domain_scores_codex":[0.999965,0.000008504702,0.000006758699,0.000004765149,0.000009048469,0.000005980428],"domain_scores_gemma":[0.9999236,0.000009922132,0.00003096242,0.000006490472,0.00001408658,0.00001498139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02505624,0.002146616,0.01607989,0.001573275,0.001059706,0.0007255063,0.0002082164,0.0006020077,0.6027468,0.0004071826,0.003025931,0.3463686],"study_design_scores_gemma":[0.006337722,0.05921524,0.5242569,0.0005163661,0.002083509,0.005606649,0.0005121786,0.003073226,0.3699148,0.001932297,0.02647635,0.00007468365],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978504,0.01728791,0.0005744486,0.0003025754,0.00005864853,0.00003303384,0.0004888263,0.00013022,0.002620343],"genre_scores_gemma":[0.9896362,0.007461799,0.00100142,0.0001595119,0.00003221991,0.00002169779,0.0003441499,0.00000865448,0.001334239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002100594,"threshold_uncertainty_score":0.007027149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02655719323789829,"score_gpt":0.3159231597293957,"score_spread":0.2893659664914974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}