{"id":"W4407419623","doi":"10.3389/fimmu.2025.1491450","title":"Diethyldithiocarbamate-copper complex ignites the tumor microenvironment through NKG2D-NKG2DL axis","year":2025,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; McGill University; McGill University Health Centre","funders":"McGill University Health Centre; McGill University","keywords":"Tumor microenvironment; NKG2D; Cytotoxicity; Cancer research; Immune system; Immunogenicity; Colorectal cancer; Tumor-infiltrating lymphocytes; Immunotherapy; Natural killer cell; Immunology; Medicine; Cancer; Biology; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005691459,0.000196708,0.0001120644,0.0001079289,0.00008360136,0.0001274861,0.0001320645,0.0001677338,0.001304286],"category_scores_gemma":[0.00008855015,0.00005761955,0.0001082339,0.00005721459,0.0001721206,0.00009094286,0.0001558963,0.0002265553,0.0001392462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001944025,"about_ca_system_score_gemma":0.000202861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003401597,"about_ca_topic_score_gemma":0.0004870995,"domain_scores_codex":[0.9999509,0.000009624648,0.000002567746,0.000008838072,0.00001202212,0.00001598013],"domain_scores_gemma":[0.9999691,0.000005072303,0.000009711215,0.000003788364,0.000002716531,0.000009561914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003533151,0.00004196134,0.0002430562,0.00008990278,0.000009775075,0.0001119669,0.00001001023,0.0001490684,0.9951864,0.0002087559,0.0002286784,0.003367161],"study_design_scores_gemma":[0.0000401071,0.0005154081,0.0009614969,0.000004641698,0.00001296858,0.0001724677,0.000009871248,0.000599544,0.9938094,0.0000746499,0.003796473,0.000002945874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898295,0.003900697,0.002040752,0.0002749843,0.00008576623,0.00004126643,0.0001346893,0.0001616018,0.003530865],"genre_scores_gemma":[0.9968388,0.0008257886,0.0006743231,0.0000520763,0.00001564422,0.00002012417,0.00007100616,0.000007471884,0.00149473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001304286,"threshold_uncertainty_score":0.004363298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009942532535288852,"score_gpt":0.2248428609573953,"score_spread":0.2149003284221065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}