{"id":"W4407420453","doi":"10.21203/rs.3.rs-5891152/v1","title":"Unanchored K63-linked polyubiquitin chains: a novel second messenger involved in G protein-coupled receptors early signaling events","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Receptor; Second messenger system; Cell biology; Signal transduction; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001539387,0.0003122673,0.0001812044,0.0002914311,0.0003509274,0.0007660252,0.0002232856,0.0005173351,0.001770426],"category_scores_gemma":[0.000151702,0.0001495572,0.0001729725,0.0002527218,0.0003715242,0.0006763228,0.0002476016,0.0004589914,0.0007396293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004139989,"about_ca_system_score_gemma":0.0001142971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001811731,"about_ca_topic_score_gemma":0.0002213539,"domain_scores_codex":[0.9999251,0.000006118236,0.000004498519,0.00002549503,0.00001913653,0.00001955247],"domain_scores_gemma":[0.9999338,0.00001079809,0.00001611541,0.00001265793,0.000008576528,0.00001808474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004245467,0.00003209349,0.0004018313,0.00006105406,0.000008609473,0.0008922556,0.00003225344,0.0001354071,0.9901212,0.002536561,0.0001567335,0.005197369],"study_design_scores_gemma":[0.00004601783,0.0001836517,0.007968571,0.000009908604,0.00003297747,0.002100612,0.00005726427,0.002118619,0.9773784,0.003432488,0.006657507,0.00001393736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764063,0.007698758,0.008344403,0.0003682857,0.0002337782,0.00001795796,0.0003241716,0.0001661883,0.006440195],"genre_scores_gemma":[0.9851977,0.001897969,0.002345335,0.00005832272,0.00009911629,0.000008057203,0.0004284624,0.00002833107,0.009936654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001770426,"threshold_uncertainty_score":0.005922675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04819101361717725,"score_gpt":0.3413388398592577,"score_spread":0.2931478262420804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}