{"id":"W4407431005","doi":"10.1016/j.bpj.2024.11.632","title":"BPS2025 - Waltz in the membrane: Unveiling the spatiotemporal dynamics of M1 muscarinic receptors and G proteins","year":2025,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Waltz; Muscarinic acetylcholine receptor; Dynamics (music); Biophysics; Chemistry; Receptor; Biology; Physics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002124812,0.0002424228,0.0002226769,0.0002103533,0.0003469806,0.0007941888,0.0003898612,0.0004591227,0.002002306],"category_scores_gemma":[0.0002259321,0.000191241,0.0001921362,0.0001993469,0.0004369629,0.001350308,0.0005797841,0.001029395,0.0005495651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005887345,"about_ca_system_score_gemma":0.0003909673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001292255,"about_ca_topic_score_gemma":0.00146002,"domain_scores_codex":[0.9999282,0.00001081703,0.000003399228,0.00001437854,0.00002420705,0.00001886931],"domain_scores_gemma":[0.9999644,0.000007800762,0.000007600426,0.000004911853,0.000004350208,0.00001101545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003119381,0.00003407066,0.0004789128,0.0001244976,0.00002251115,0.0002256785,0.00009534946,0.002317511,0.9650288,0.01591535,0.0009440003,0.01450128],"study_design_scores_gemma":[0.0001096205,0.0002587816,0.004727321,0.00005406761,0.00006296194,0.0006744669,0.0003764885,0.1148361,0.8396724,0.01305828,0.02609933,0.00007019198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9601282,0.003146432,0.02710568,0.002548219,0.000235668,0.00001834797,0.0003419169,0.000359375,0.006116046],"genre_scores_gemma":[0.9848834,0.002752663,0.008314051,0.0004854241,0.00005396344,0.00001475508,0.0002522794,0.0001072988,0.00313608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002002306,"threshold_uncertainty_score":0.00669837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007103351606494617,"score_gpt":0.2433292243534199,"score_spread":0.2362258727469253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}