{"id":"W4407434644","doi":"10.1371/journal.ppat.1012922","title":"Intracellular Pseudomonas aeruginosa persist and evade antibiotic treatment in a wound infection model","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Horizon 2020 Framework Programme; Association Vaincre la Mucoviscidose; CIHR Skin Research Training Centre; Killam Trusts; Agence Nationale de la Recherche","keywords":"Pseudomonas aeruginosa; Microbiology; Antibiotics; Zebrafish; Biofilm; Cystic fibrosis; Biology; Intracellular parasite; In vivo; Bacteria; Innate immune system; Immunity; Chronic infection; Immune system; Multidrug tolerance; Intracellular; Antibiotic resistance; Immunology; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006421645,0.0001528804,0.0001567969,0.0000753901,0.00007577206,0.00003509438,0.000033233,0.000159287,0.000002813683],"category_scores_gemma":[0.00002705123,0.0001444068,0.00005825517,0.00009157262,0.00005205395,0.000003943604,0.00004873865,0.00004441038,0.000002805484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004330251,"about_ca_system_score_gemma":0.00006780485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008344578,"about_ca_topic_score_gemma":0.0001993901,"domain_scores_codex":[0.9992182,0.00004158943,0.0001516832,0.0003346853,0.00004705523,0.0002067639],"domain_scores_gemma":[0.9996911,0.000006575929,0.00003419483,0.0001946537,0.00002662954,0.00004688603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004968047,0.0001472281,0.01441111,0.00002587487,0.00004745467,0.000009246348,0.00007112763,0.00009905927,0.9825128,0.00006235648,0.00002047367,0.002543534],"study_design_scores_gemma":[0.0008552673,0.0002400283,0.01125867,0.00005372582,0.00009381615,0.00001341276,0.00005422902,0.006318927,0.9796319,0.00003414215,0.001212382,0.000233518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982508,0.0005038386,0.0001166698,0.0001551916,0.00008519301,0.0002198663,0.00002221495,0.00001258163,0.0006335865],"genre_scores_gemma":[0.9981597,0.000552386,0.0007096128,0.00009379361,0.00006408498,0.000005132607,0.00006533576,0.00001170135,0.000338266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006219868,"threshold_uncertainty_score":0.5888737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01278428710163947,"score_gpt":0.2334666795848098,"score_spread":0.2206823924831704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}