{"id":"W4407434644","doi":"10.1371/journal.ppat.1012922","title":"Intracellular Pseudomonas aeruginosa persist and evade antibiotic treatment in a wound infection model","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Horizon 2020 Framework Programme; Association Vaincre la Mucoviscidose; CIHR Skin Research Training Centre; Killam Trusts; Agence Nationale de la Recherche","keywords":"Pseudomonas aeruginosa; Microbiology; Antibiotics; Zebrafish; Biofilm; Cystic fibrosis; Biology; Intracellular parasite; In vivo; Bacteria; Innate immune system; Immunity; Chronic infection; Immune system; Multidrug tolerance; Intracellular; Antibiotic resistance; Immunology; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001547266,0.0003997594,0.0002979772,0.0002271936,0.0002068015,0.0002250026,0.0002448332,0.0005142037,0.001009282],"category_scores_gemma":[0.0001039122,0.000169356,0.0003082622,0.00008304588,0.0002669328,0.0003273439,0.0003492008,0.0009301268,0.0002117628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003273654,"about_ca_system_score_gemma":0.0003000889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001834382,"about_ca_topic_score_gemma":0.003032875,"domain_scores_codex":[0.9998252,0.00001447951,0.00001519067,0.00004303427,0.00006243238,0.00003980216],"domain_scores_gemma":[0.999889,0.00001297867,0.00003569411,0.00001485672,0.00001780849,0.00002974725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002140406,0.00001224905,0.00006944786,0.00002029812,0.000001399259,0.00003398413,0.0000156514,0.00002516828,0.9993715,0.00004781355,0.00002675082,0.0003543439],"study_design_scores_gemma":[0.00001405166,0.0006426555,0.003821295,0.00001836153,0.0000180186,0.0002419804,0.00005803459,0.001365022,0.991998,0.000072692,0.001738627,0.00001123718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860071,0.001232309,0.009912722,0.0002502276,0.00008162887,0.000103518,0.0004783665,0.0001397507,0.001794349],"genre_scores_gemma":[0.9841684,0.001065928,0.008420453,0.0001195662,0.00001166532,0.0001355135,0.0003515671,0.00003606179,0.005690909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001834382,"threshold_uncertainty_score":0.003647447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01278428710163947,"score_gpt":0.2334666795848098,"score_spread":0.2206823924831704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}