{"id":"W4407437595","doi":"10.1016/j.molmet.2025.102112","title":"The neglected PCK1/glucagon (inter)action in nutrient homeostasis beyond gluconeogenesis: Disease pathogenesis and treatment","year":2025,"lang":"en","type":"review","venue":"Molecular Metabolism","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Fondo Nacional de Desarrollo Científico y Tecnológico","keywords":"Gluconeogenesis; Glucose homeostasis; Pathogenesis; Homeostasis; Medicine; Glucagon; Disease; Diabetes mellitus; Endocrinology; Internal medicine; Insulin; Insulin resistance; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002361664,0.0008969302,0.001518348,0.0003052798,0.0002262281,0.0001551298,0.0004501054,0.000396436,0.00001362002],"category_scores_gemma":[0.00017848,0.0006521447,0.0008374626,0.0005709573,0.0002019635,0.000009826733,0.0002415102,0.0002019004,0.000009130307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001190491,"about_ca_system_score_gemma":0.0007274766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006043035,"about_ca_topic_score_gemma":0.0001130605,"domain_scores_codex":[0.9961954,0.0008010818,0.0008112102,0.001209926,0.0002944554,0.0006879373],"domain_scores_gemma":[0.9979473,0.00005743395,0.000346608,0.001221963,0.0001237183,0.0003029562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007794868,0.0001303575,0.000003934235,0.00123348,0.0004980916,0.00003457819,0.00001778102,0.00000238483,0.0008329769,0.0002337184,0.0001738245,0.9967609],"study_design_scores_gemma":[0.0007853632,0.0000546759,0.00008426946,0.0007854177,0.002410107,0.000007559622,0.00002631577,0.000002446257,0.003200704,0.0001334337,0.9919031,0.0006066473],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004179201,0.9926177,0.0002316571,0.00003405297,0.001049623,0.001472131,0.0003349634,0.00002661713,0.00005400878],"genre_scores_gemma":[0.0002764502,0.9961674,0.00006388019,0.0002195282,0.0003784131,0.00152636,0.0008463199,0.0001071016,0.0004146022],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9961542,"threshold_uncertainty_score":0.999593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01686282770408967,"score_gpt":0.2917261965505011,"score_spread":0.2748633688464115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}