{"id":"W4407439320","doi":"10.1055/s-0044-1801605","title":"Long-term Outcomes With Efanesoctocog Alfa Prophylaxis for Previously Treated Children With Severe Hemophilia A, an Interim Analysis of the Phase 3 XTEND-ed Study","year":2025,"lang":"en","type":"article","venue":"Hämostaseologie","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; McMaster Children's Hospital","funders":"","keywords":"Interim; Interim analysis; Term (time); Medicine; Phase (matter); Pediatrics; Internal medicine; Clinical trial; Political science; Chemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003121625,0.0003846202,0.001022709,0.0004323879,0.0001890184,0.00003101744,0.0003840991,0.0001275829,0.000113899],"category_scores_gemma":[0.0001573092,0.0001737811,0.0002845971,0.001599984,0.0003596533,0.0000888841,0.000127637,0.0002382696,0.000001986418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000131714,"about_ca_system_score_gemma":0.000330871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000148034,"about_ca_topic_score_gemma":0.0003865979,"domain_scores_codex":[0.9977374,0.0001954383,0.000424916,0.0006482478,0.0005024623,0.0004915385],"domain_scores_gemma":[0.9979728,0.0001765479,0.0001690427,0.0011914,0.0003415506,0.0001486172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004651829,0.005175035,0.9665386,0.0001195791,0.008102354,0.000107368,0.000337883,0.00002097536,0.0001673487,0.000007410811,0.00009202531,0.01467961],"study_design_scores_gemma":[0.01422642,0.01227985,0.9628522,0.0001306516,0.006764907,0.00002239978,0.0003231061,0.0001088878,0.003069342,0.000007955647,0.00001023634,0.0002040066],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911284,0.0001721573,0.00007013128,0.0006292377,0.00002649647,0.00753699,0.0002022476,0.00009199825,0.0001423399],"genre_scores_gemma":[0.9959499,0.00002386429,0.0002266968,0.0001132379,0.00001821533,0.0005464338,0.0005419307,0.0000295533,0.002550124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0144756,"threshold_uncertainty_score":0.7086587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05062536910077066,"score_gpt":0.391958740921043,"score_spread":0.3413333718202724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}