{"id":"W4407439433","doi":"10.1055/s-0044-1801608","title":"First Interim Analysis of Clinical Outcomes in Adults and Adolescents With Severe Hemophilia A Receiving Efanesoctocog Alfa Prophylaxis in XTEND-ed, a Phase 3 Long-term Extension Study","year":2025,"lang":"en","type":"article","venue":"Hämostaseologie","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Interim; Interim analysis; Medicine; Term (time); Pediatrics; Clinical trial; Internal medicine; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004149253,0.001520546,0.003404923,0.0003414627,0.0006269612,0.001489689,0.0006815049,0.001125186,0.003669793],"category_scores_gemma":[0.003245312,0.0005056879,0.003540274,0.0003584705,0.0006976454,0.00122118,0.0006294919,0.002900281,0.0005960228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006870807,"about_ca_system_score_gemma":0.001178729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007199353,"about_ca_topic_score_gemma":0.001075862,"domain_scores_codex":[0.9984733,0.0006784905,0.00007979706,0.0002244791,0.0001671785,0.0003766775],"domain_scores_gemma":[0.9973284,0.0007271972,0.0006633663,0.0004974653,0.0002296656,0.0005538525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9397888,0.007201934,0.02170897,0.0003060549,0.004485127,0.0001233119,0.0001222959,0.001126394,0.002022359,0.0001879852,0.001924144,0.02100274],"study_design_scores_gemma":[0.4132163,0.381825,0.1861818,0.0001265487,0.00907749,0.0002859843,0.000219653,0.002298875,0.002446846,0.0007281086,0.003495628,0.00009791042],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913048,0.002441442,0.0008060798,0.0001781215,0.0001227612,0.0008536725,0.002890087,0.0000649007,0.001338238],"genre_scores_gemma":[0.9892018,0.000625302,0.0007750886,0.0003829557,0.0001446363,0.001580243,0.004914234,0.00002470979,0.002351125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004149253,"threshold_uncertainty_score":0.02194363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06124121703835467,"score_gpt":0.4247560751161429,"score_spread":0.3635148580777883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}