{"id":"W4407439433","doi":"10.1055/s-0044-1801608","title":"First Interim Analysis of Clinical Outcomes in Adults and Adolescents With Severe Hemophilia A Receiving Efanesoctocog Alfa Prophylaxis in XTEND-ed, a Phase 3 Long-term Extension Study","year":2025,"lang":"en","type":"article","venue":"Hämostaseologie","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Interim; Interim analysis; Medicine; Term (time); Pediatrics; Clinical trial; Internal medicine; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008646116,0.0002871204,0.001366476,0.001033094,0.00005248168,0.000014711,0.0001608066,0.0001959084,0.00004553639],"category_scores_gemma":[0.001024523,0.0001859786,0.000173152,0.001592052,0.0002563802,0.00008009994,0.0002541987,0.000494862,0.000002792063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001177821,"about_ca_system_score_gemma":0.0001760218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003206144,"about_ca_topic_score_gemma":0.002490351,"domain_scores_codex":[0.9971921,0.0002868948,0.0009370029,0.0007491939,0.0004221761,0.0004126745],"domain_scores_gemma":[0.998581,0.0003562764,0.0001568357,0.0006015291,0.0001601551,0.0001442061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009370751,0.008594158,0.9508427,0.0005643063,0.0006287939,0.002359744,0.0004787823,0.000009132114,0.00002330725,9.807164e-7,0.00001617906,0.02711118],"study_design_scores_gemma":[0.01965404,0.003785166,0.972321,0.002418041,0.0005344026,0.00001084911,0.0005448985,0.0005133805,0.00005287182,0.000006122243,0.000002958596,0.0001562176],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966336,0.0003097739,0.000009113973,0.0005407379,0.00005591347,0.002350045,0.00002312842,0.00003170387,0.00004599905],"genre_scores_gemma":[0.9990922,0.0003582361,0.0001114561,0.00008100118,0.00001230581,0.0001018087,0.00004752545,0.00001473438,0.00018077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02695497,"threshold_uncertainty_score":0.7583987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06124121703835467,"score_gpt":0.4247560751161429,"score_spread":0.3635148580777883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}