{"id":"W4407445867","doi":"10.1016/j.bpj.2024.11.1890","title":"BPS2025 - Structural investigation of an intermediate state of KCNQ1","year":2025,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Thermal and Kinetic Analysis","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"State (computer science); Computational biology; Chemistry; Biology; Computer science; Algorithm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001356691,0.00007028033,0.000202519,0.00007801845,0.00004050386,0.00002404036,0.0002082929,0.00002103104,0.0001157178],"category_scores_gemma":[0.00002370834,0.00004976378,0.0000815543,0.0001747023,0.0001978812,0.000142383,0.00004602754,0.00008394148,0.000006354818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001372337,"about_ca_system_score_gemma":0.00005215954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003612538,"about_ca_topic_score_gemma":0.000003352657,"domain_scores_codex":[0.9992127,0.00008513396,0.0003217984,0.00009382814,0.0001764217,0.0001101532],"domain_scores_gemma":[0.9994714,0.00002678903,0.0002117559,0.0001083229,0.0001105124,0.00007128099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005145696,0.00001565768,0.0004865897,0.00001808905,0.00001782686,0.000001791579,0.000182478,0.0001031127,0.993179,0.00036273,0.00001687532,0.005564359],"study_design_scores_gemma":[0.0002113539,0.0001102682,0.08046082,0.00004829294,0.00004224054,0.000002735828,0.00004512177,0.001641308,0.9106154,0.006763213,0.000007878795,0.00005140371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991143,0.00001181105,0.0004711593,0.00009036474,0.0002047496,0.00002577998,0.00001745639,0.000006816352,0.00005753894],"genre_scores_gemma":[0.9991526,0.000004705403,0.000623102,0.00004298733,0.00008131281,5.004126e-7,0.000002283978,0.000002871999,0.0000896228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08256367,"threshold_uncertainty_score":0.2029308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00792838140413478,"score_gpt":0.2507150236942308,"score_spread":0.2427866422900961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}