{"id":"W4407450545","doi":"10.1038/s41598-025-86767-5","title":"High intensity interval training alters gene expression linked to mitochondrial biogenesis and dynamics in high fat diet fed rats","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University","keywords":"FIS1; Mitochondrial biogenesis; MFN2; High-intensity interval training; TFAM; Biology; Endocrinology; Internal medicine; Endurance training; PPARGC1A; Gene expression; Mitochondrial fission; mitochondrial fusion; Andrology; Mitochondrion; Gene; Medicine; Cell biology; Mitochondrial DNA; Transcription factor; Genetics; Coactivator","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009894004,0.000370298,0.0003010793,0.0004107784,0.0001358229,0.0001516566,0.0001171918,0.0002177297,0.001065565],"category_scores_gemma":[0.00008728807,0.0001829167,0.0002340149,0.0001860437,0.0002720119,0.0001626086,0.0001536182,0.0004778504,0.0001225886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001648045,"about_ca_system_score_gemma":0.0001221614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007834071,"about_ca_topic_score_gemma":0.0008673749,"domain_scores_codex":[0.9999083,0.000009483027,0.00000793008,0.00002870719,0.000015033,0.00003047376],"domain_scores_gemma":[0.999863,0.00000805408,0.00004811612,0.00001269212,0.00001499623,0.00005301938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003074617,0.0004213284,0.003492604,0.00004269166,0.00002290773,0.00007941052,0.00004563016,0.00004642518,0.9899989,0.00002907675,0.00004007153,0.002706427],"study_design_scores_gemma":[0.0003113702,0.01392124,0.3575765,0.00002940134,0.0002144184,0.0005703875,0.0005026821,0.001734477,0.6233912,0.0001766543,0.001535854,0.00003581473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993778,0.000149258,0.0002692449,0.00001871082,0.000008625627,0.000004404132,0.00005763141,0.00000963542,0.0001046243],"genre_scores_gemma":[0.9967025,0.0004755332,0.000755053,0.00006177603,0.00001253324,0.00005962341,0.000267916,0.00001046658,0.001654667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001065565,"threshold_uncertainty_score":0.003564656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02130644981699002,"score_gpt":0.2773527132796693,"score_spread":0.2560462634626793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}