{"id":"W4407461011","doi":"10.1016/s0140-6736(25)00193-x","title":"Efficacy and safety of intravenous nerinetide initiated by paramedics in the field for acute cerebral ischaemia within 3 h of symptom onset (FRONTIER): a phase 2, multicentre, randomised, double-blind, placebo-controlled study","year":2025,"lang":"en","type":"article","venue":"The Lancet","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trillium Health Centre; Foothills Medical Centre; BC Mental Health & Substance Use Services; NoNO (Canada); Health Sciences Centre; University Health Network; University of Toronto; University of British Columbia Hospital; Kelowna General Hospital; St. Michael's Hospital; Sunnybrook Health Science Centre; University of Calgary; Royal Columbian Hospital; University of British Columbia","funders":"University of Toronto; Royal Historical Society; Fondation Brain Canada; University of Calgary; Minnesota Department of Health","keywords":"Medicine; Placebo; Cerebral ischaemia; Anesthesia; Double blind; Randomized controlled trial; Ischemia; Emergency medicine; Internal medicine; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001425772,0.001427032,0.003699491,0.0004290432,0.0004193216,0.001110476,0.001019577,0.002678656,0.004906686],"category_scores_gemma":[0.001735798,0.000814778,0.001695443,0.0003261434,0.001375537,0.001232929,0.000380617,0.002530692,0.001083593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005152063,"about_ca_system_score_gemma":0.000932214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006710638,"about_ca_topic_score_gemma":0.001208694,"domain_scores_codex":[0.9994394,0.0002637555,0.00004189903,0.0001102188,0.0000409594,0.0001036169],"domain_scores_gemma":[0.9991592,0.0002604508,0.0001902042,0.00007280525,0.00006192286,0.0002554352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.98333,0.005524467,0.0001929352,0.0004950421,0.0003858548,0.00002708635,0.00003674298,0.00008609091,0.002888888,0.00004040822,0.0002218141,0.006770609],"study_design_scores_gemma":[0.9179808,0.08008676,0.001095279,0.00002598238,0.0002229097,0.00001887212,0.00001847783,0.0001044981,0.0002369578,0.00004238039,0.000154341,0.00001280096],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927015,0.00366048,0.0003841691,0.0002885593,0.0004220109,0.001253818,0.000344299,0.00006238859,0.0008827433],"genre_scores_gemma":[0.9899951,0.003308543,0.00112541,0.0007960506,0.0006804054,0.001951231,0.0004818902,0.00002048413,0.001640911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004906686,"threshold_uncertainty_score":0.01641452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02372975587288453,"score_gpt":0.3420719876112688,"score_spread":0.3183422317383843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}