{"id":"W4407481065","doi":"10.1016/j.stemcr.2025.102418","title":"Clonal lineage tracing and transcriptomics of cortical progenitor populations reveal maintenance of differentiation potential","year":2025,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Canada Research Chairs","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Progenitor; Progenitor cell; Transcriptome; Lineage (genetic); Evolutionary biology; Cell lineage; Cellular differentiation; Stem cell; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001341531,0.0001102254,0.0001994898,0.00004483424,0.00005182323,0.000008978505,0.00004879879,0.0001315794,0.000002664057],"category_scores_gemma":[0.00001446149,0.0001066277,0.0001107285,0.00006754402,0.00007710648,0.000004323052,0.00002022755,0.00007866547,5.878994e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008297266,"about_ca_system_score_gemma":0.00007315788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000270717,"about_ca_topic_score_gemma":0.00002185553,"domain_scores_codex":[0.998923,0.00003815156,0.0005461819,0.0002478933,0.0001118649,0.0001328881],"domain_scores_gemma":[0.999447,0.000007109867,0.0001965629,0.0001923789,0.00011482,0.00004210897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001031964,0.0001262548,0.04393559,0.0001854109,0.00003106299,0.000008282361,0.0000522052,0.00006745781,0.9544822,0.0000769268,0.00005619272,0.0008752342],"study_design_scores_gemma":[0.0004480481,0.0001200165,0.04685943,0.00006373031,0.0001071512,0.00003259212,0.00006481999,0.0005754692,0.9513523,0.00008941983,0.0001700827,0.0001169454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759727,0.000410545,0.02259786,0.00002297556,0.0004413718,0.0002055572,0.00002007015,0.000006573899,0.0003224105],"genre_scores_gemma":[0.9983239,0.00004418406,0.0008819543,0.00001546622,0.00005665996,0.000006180619,0.00007776615,0.00001089169,0.000583018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02235124,"threshold_uncertainty_score":0.4348153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01033742223733471,"score_gpt":0.2304736950333894,"score_spread":0.2201362727960547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}