{"id":"W4407508389","doi":"10.1159/000544111","title":"Histamine Promotes Pseudomonas aeruginosa Biofilm Formation and Renders P. aeruginosa Biofilms More Resistant to Gentamicin and Azithromycin","year":2025,"lang":"en","type":"article","venue":"Medical Principles and Practice","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast","keywords":"Biofilm; Pseudomonas aeruginosa; Microbiology; Histamine; Galleria mellonella; Gentamicin; Virulence; Chemistry; Bacteria; Biology; Antibiotics; Pharmacology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008056003,0.000223773,0.000234798,0.00008352617,0.0002213022,0.0001033736,0.00009573784,0.0002541564,0.00001497029],"category_scores_gemma":[0.001723003,0.0001910724,0.00003067246,0.0001362287,0.0002276045,0.00003406957,0.0003360037,0.0001816994,0.00000179231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002131111,"about_ca_system_score_gemma":0.00009859326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002003519,"about_ca_topic_score_gemma":0.000141731,"domain_scores_codex":[0.9984631,0.0001639685,0.0003546949,0.000489225,0.000226041,0.0003029916],"domain_scores_gemma":[0.9991011,0.0001612001,0.0001262407,0.0002500204,0.00008114205,0.0002802742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006786074,0.0000671442,0.0004899014,0.0001748276,0.00007272836,0.00002857944,0.0002706818,5.780345e-7,0.9629069,0.001244501,0.001795345,0.03227023],"study_design_scores_gemma":[0.001690023,0.0006643326,0.01133403,0.0002853586,0.0001617028,0.0004431044,0.001732028,0.0004554246,0.1773483,0.0000328339,0.8053346,0.0005182679],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9690708,0.002696112,0.0005446653,0.02561623,0.0001699248,0.0003596738,0.00002621731,0.00002365785,0.001492719],"genre_scores_gemma":[0.9854001,0.003288454,0.006439616,0.004067592,0.0001585631,0.00001164529,0.0001125788,0.00001821047,0.0005031996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8035392,"threshold_uncertainty_score":0.7791706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599454209894092,"score_gpt":0.2860998524591783,"score_spread":0.2701053103602374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}