{"id":"W4407508389","doi":"10.1159/000544111","title":"Histamine Promotes Pseudomonas aeruginosa Biofilm Formation and Renders P. aeruginosa Biofilms More Resistant to Gentamicin and Azithromycin","year":2025,"lang":"en","type":"article","venue":"Medical Principles and Practice","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast","keywords":"Biofilm; Pseudomonas aeruginosa; Microbiology; Histamine; Galleria mellonella; Gentamicin; Virulence; Chemistry; Bacteria; Biology; Antibiotics; Pharmacology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000145131,0.0003532153,0.0002806082,0.0002597222,0.0001497923,0.0003329805,0.0002087015,0.000401597,0.002314525],"category_scores_gemma":[0.0001481395,0.0001932157,0.0003358917,0.0001167224,0.000199291,0.0001975041,0.0003847055,0.0006255854,0.0003804303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003228724,"about_ca_system_score_gemma":0.0001892125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001499134,"about_ca_topic_score_gemma":0.002110757,"domain_scores_codex":[0.9997498,0.00003709506,0.00002257253,0.00003711045,0.00008890634,0.00006449036],"domain_scores_gemma":[0.9998645,0.00002055312,0.00004013906,0.00001451327,0.00001956679,0.00004069832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000595998,0.00002739321,0.0001552588,0.00002194273,0.00000273023,0.0000247297,0.000007387745,0.000009970902,0.9992366,0.000008021998,0.00002876857,0.0004176463],"study_design_scores_gemma":[0.0000368145,0.001239465,0.03472215,0.00002563836,0.00002403011,0.0003067087,0.00007985273,0.0007686201,0.9609361,0.00003240746,0.001818053,0.00001016498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969817,0.001148636,0.0005434498,0.0001416537,0.00002677113,0.00003113173,0.0002088897,0.00004653942,0.0008712753],"genre_scores_gemma":[0.9962924,0.0005885733,0.001076692,0.00006588155,0.00001429874,0.00002614441,0.0002746783,0.00001042055,0.001650992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002314525,"threshold_uncertainty_score":0.007742882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599454209894092,"score_gpt":0.2860998524591783,"score_spread":0.2701053103602374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}