{"id":"W4407548420","doi":"10.1002/mds.30148","title":"Selective Effects of Substantia Nigra and Locus Coeruleus Degeneration on Cognition in Parkinson's Disease","year":2025,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Hôpital du Sacré-Cœur de Montréal; Université du Québec à Montréal; Montreal Neurological Institute and Hospital; McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Neuromelanin; Substantia nigra; Locus coeruleus; Neuroscience; Psychology; Cognition; Dopaminergic; Parkinson's disease; Working memory; Dopamine; Executive functions; Audiology; Medicine; Disease; Internal medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001030437,0.0004404868,0.0004899346,0.00109305,0.0004281227,0.0005466476,0.0002777753,0.0005604735,0.0006029371],"category_scores_gemma":[0.001703759,0.0002121008,0.0005163859,0.0003717902,0.0007243152,0.0002519212,0.0005436673,0.000389274,0.0000588708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006919671,"about_ca_system_score_gemma":0.0003775204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006709731,"about_ca_topic_score_gemma":0.01384172,"domain_scores_codex":[0.9995992,0.00009449339,0.00003997353,0.0001247691,0.000106253,0.00003539611],"domain_scores_gemma":[0.9986354,0.000299601,0.0005829992,0.00009099738,0.0001914986,0.0001995238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001938893,0.0001437249,0.9805394,0.00005917236,0.0007056699,0.0003786895,0.0001370022,0.0001580864,0.009036326,0.00003526438,0.00005585639,0.006811879],"study_design_scores_gemma":[0.000005462353,0.0001702076,0.9992175,0.000003997754,0.00007422741,0.0001914625,0.00002304158,0.00004856602,0.0002049569,0.00002883933,0.00003010231,0.000001625749],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982947,0.001244619,0.00005664859,0.00003890602,0.000002405723,0.000004819572,0.00006183756,0.000003555608,0.0002925249],"genre_scores_gemma":[0.9995193,0.0001872925,0.0001025951,0.00003165284,0.000004017248,0.0000030028,0.00007518133,0.000001271708,0.00007564334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006709731,"threshold_uncertainty_score":0.01334137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00487968308693626,"score_gpt":0.23798155882893,"score_spread":0.2331018757419937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}