{"id":"W4407551147","doi":"10.3389/fragi.2025.1512322","title":"Klotho protects INS-1 pancreatic β-cells from senescence and enhances mitochondrial function","year":2025,"lang":"en","type":"article","venue":"Frontiers in Aging","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"National Natural Science Foundation of China","keywords":"Senescence; Downregulation and upregulation; Paracrine signalling; Klotho; Biology; Cell biology; Endocrinology; Cell; Internal medicine; Receptor; Medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009551682,0.0001339412,0.0003227821,0.0002250018,0.00006613651,0.00003239218,0.000043128,0.00007998901,0.00003841459],"category_scores_gemma":[0.0001655846,0.0001225291,0.00003549029,0.0002917667,0.00006999647,0.000102483,0.00002658162,0.0001657011,0.000007329682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007495202,"about_ca_system_score_gemma":0.00007439216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001609861,"about_ca_topic_score_gemma":0.000007779499,"domain_scores_codex":[0.9990976,0.0000542292,0.0002081107,0.0003094088,0.0001312738,0.0001993606],"domain_scores_gemma":[0.9996006,0.00007863199,0.00005123992,0.0001785189,0.00002695557,0.00006409025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008627803,0.0001349601,0.351707,0.0004327121,0.0002063956,0.00002570729,0.0006916156,0.00001781061,0.5786042,0.0000748079,0.0155898,0.05165222],"study_design_scores_gemma":[0.01392127,0.0004517503,0.2654846,0.005696125,0.0008002747,0.000006555925,0.004357792,0.01711207,0.6480338,0.007651371,0.03566597,0.0008184046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8837602,0.003585614,0.1038102,0.0004214832,0.003565246,0.0006029757,0.000003781504,0.0001016264,0.004148977],"genre_scores_gemma":[0.9678755,0.0002504285,0.02593882,0.001024071,0.0003441632,0.00009099723,0.00001707323,0.00001567518,0.004443307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08622239,"threshold_uncertainty_score":0.4996592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005982588583383557,"score_gpt":0.2258990129984972,"score_spread":0.2199164244151136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}