{"id":"W4407554413","doi":"10.3389/fphar.2025.1538520","title":"Saliva-derived components can enhance the performance of toluidine blue in photodynamic therapy","year":2025,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Photodynamic therapy; Photosensitizer; Saliva; Cytotoxic T cell; Cancer research; Chemistry; Head and neck squamous-cell carcinoma; Cytotoxicity; Reactive oxygen species; Cell culture; Cancer cell; Head and neck cancer; Basal cell; Medicine; Pharmacology; Cancer; Pathology; Internal medicine; Biology; Biochemistry; In vitro; Photochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004526868,0.0001901008,0.0005823924,0.0004386868,0.00006333463,0.00000353123,0.0003603659,0.00008767199,0.0000599577],"category_scores_gemma":[0.00003261481,0.0001433333,0.00006807174,0.0006909004,0.0004732812,0.00004218169,0.0001085514,0.0004861739,0.000001343449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003351031,"about_ca_system_score_gemma":0.000198392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002762566,"about_ca_topic_score_gemma":0.0001245819,"domain_scores_codex":[0.9983761,0.000241434,0.0004290471,0.0002953305,0.0001944777,0.0004636504],"domain_scores_gemma":[0.9994068,0.0001358977,0.00009290017,0.0002497173,0.00006907237,0.00004561352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002970021,0.0003794373,0.05465778,0.0001083273,0.0003252309,0.00003039553,0.001014921,0.0001461171,0.9291357,0.000005134539,0.004731569,0.00649537],"study_design_scores_gemma":[0.007468842,0.0004239201,0.224428,0.0001715356,0.00003781115,0.000006586554,0.0005014236,0.01849031,0.7463326,0.00008684306,0.001891132,0.0001609336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906867,0.003725279,0.00005400954,0.0028279,0.001072444,0.001190284,0.00001317892,0.00002297557,0.0004072043],"genre_scores_gemma":[0.9847737,0.01298022,0.0001700282,0.001284458,0.00003398127,0.0002362567,0.00001277022,0.00001571568,0.0004928675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.182803,"threshold_uncertainty_score":0.5844962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01237663857240288,"score_gpt":0.32601843735942,"score_spread":0.3136417987870171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}