{"id":"W4407564894","doi":"10.1158/1078-0432.ccr-24-1210","title":"Prevalence of Mismatch Repair Deficiency in Primary Prostate Cancer in a Large Prospective Cohort","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Eisai; Daiichi-Sankyo; Irish Cancer Society; Wellcome Trust; Harvard T.H. Chan School of Public Health; Harvard University; National Cancer Institute; Brigham and Women's Hospital; Prostate Cancer Foundation; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Amgen; Pfizer; Revolution Medicines","keywords":"MSH2; Medicine; Microsatellite instability; MSH6; PMS2; Prostate cancer; Lynch syndrome; Prostate; Prospective cohort study; MLH1; Prostatectomy; Tissue microarray; Oncology; Internal medicine; Cancer; Pathology; DNA mismatch repair; Colorectal cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001003979,0.0003278496,0.0004482782,0.0007510873,0.0006575198,0.0006653614,0.0004636845,0.0005559471,0.001837552],"category_scores_gemma":[0.002081891,0.0005178504,0.0003518421,0.000731745,0.0004581777,0.0004412809,0.0005308616,0.0005903406,0.0003528753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002373305,"about_ca_system_score_gemma":0.0003921657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002528467,"about_ca_topic_score_gemma":0.002547914,"domain_scores_codex":[0.9990581,0.000278347,0.000070873,0.0003265488,0.0001688737,0.00009731823],"domain_scores_gemma":[0.9985707,0.0002864281,0.0004635327,0.0002309855,0.0001230548,0.0003252331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007270928,0.00001710953,0.9992029,0.000003985989,0.0000305028,0.00006090315,0.0000243114,0.0000119569,0.0002434398,0.000004409505,0.00003126293,0.0002966037],"study_design_scores_gemma":[0.000009778828,0.0001292547,0.9987248,0.00000250447,0.00003175316,0.0007610046,0.00007486068,0.0000895297,0.00008540858,0.000009765735,0.00007841171,0.000002906558],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994012,0.0001778254,0.00009433352,0.00002171198,0.000004834901,0.000008187239,0.0001756032,0.000004628474,0.0001116069],"genre_scores_gemma":[0.9996204,0.00005735433,0.0000514016,0.00001344083,0.000007563912,0.000007539498,0.0001888244,0.000001435731,0.0000520975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002528467,"threshold_uncertainty_score":0.006147206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06988423598424741,"score_gpt":0.4880654356920638,"score_spread":0.4181811997078164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}