{"id":"W4407568767","doi":"10.1101/2025.02.14.25322265","title":"Development and validation of a machine learning model to predict cognitive behavioral therapy outcome in obsessive-compulsive disorder using clinical and neuroimaging data","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Instituto de Salud Carlos III; National Institute of Mental Health; South African Medical Research Council; Medical Research Council; Universitat de Barcelona; Agència de Gestió d'Ajuts Universitaris i de Recerca; International OCD Foundation","keywords":"Neuroimaging; Obsessive compulsive; Psychology; Cognition; Cognitive behavioral therapy; Clinical psychology; Medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008740623,0.0012958,0.00121075,0.002357648,0.0005106559,0.001530702,0.001184216,0.001280767,0.000882857],"category_scores_gemma":[0.01456872,0.0004740251,0.001416939,0.000954864,0.0003555966,0.0007556447,0.0007156889,0.001588798,0.000481919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008142816,"about_ca_system_score_gemma":0.001788362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01063248,"about_ca_topic_score_gemma":0.005533039,"domain_scores_codex":[0.9985242,0.0009132451,0.0001063607,0.0002326445,0.000113965,0.0001095231],"domain_scores_gemma":[0.9878688,0.01019104,0.0004395205,0.0002897784,0.001018627,0.0001921451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001376226,0.001377927,0.2448468,0.0001937611,0.001413396,0.0002441987,0.000157602,0.5560926,0.00151214,0.0006128359,0.003434136,0.1887384],"study_design_scores_gemma":[0.00003194787,0.0001689596,0.007032533,0.00002315918,0.00007180078,0.00002811263,0.00002498017,0.9917046,0.0002806258,0.0004890767,0.0001325618,0.00001155304],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8265938,0.001572074,0.1647708,0.001247075,0.0001354464,0.0005271306,0.002044081,0.001581301,0.001528339],"genre_scores_gemma":[0.9624286,0.0002202138,0.03408899,0.0001330219,0.00004540891,0.0003118536,0.002336248,0.00003648837,0.0003991037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01063248,"threshold_uncertainty_score":0.04622537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1570501255835791,"score_gpt":0.4378885509843309,"score_spread":0.2808384254007519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}