{"id":"W4407573143","doi":"10.1139/bcb-2024-0264","title":"Doxorubicin, a DNA intercalator, inhibits transcription elongation","year":2025,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Research Institute in Oncology and Hematology; University of Manitoba","funders":"Canadian Institutes of Health Research; CancerCare Manitoba Foundation","keywords":"H3K4me3; Doxorubicin; Promoter; Histone H3; Histone; Nucleosome; Chromatin; RNA polymerase II; Enhancer; Molecular biology; Biology; Chromatin immunoprecipitation; DNA; Chemistry; Cell biology; Biochemistry; Transcription factor; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001315481,0.0002849406,0.0002110941,0.0001882054,0.0001207219,0.0001947689,0.0001422344,0.0002295941,0.001379997],"category_scores_gemma":[0.0001488815,0.0001470528,0.0001394142,0.00009656834,0.0001384352,0.0001328034,0.0001329146,0.0003909408,0.0004250106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002970197,"about_ca_system_score_gemma":0.000152532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005472474,"about_ca_topic_score_gemma":0.001168012,"domain_scores_codex":[0.9998895,0.00002276438,0.00001222316,0.00002559156,0.00003024345,0.00001957125],"domain_scores_gemma":[0.9999112,0.00002454663,0.00002483242,0.00001067846,0.00001209609,0.00001676531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007478359,0.00001401236,0.00008421732,0.00004092589,0.00000351315,0.00001010339,0.000004951454,0.00004323328,0.9973645,0.00006533492,0.00008752157,0.002206932],"study_design_scores_gemma":[0.00001996939,0.0003520529,0.001398773,0.000007420304,0.000006410962,0.000071774,0.000004194551,0.0004919539,0.9939703,0.00002361708,0.003650319,0.000003265826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9543266,0.02224635,0.01415969,0.0003868807,0.0002306289,0.0001036672,0.0007412708,0.0004500987,0.007354724],"genre_scores_gemma":[0.9837821,0.004247349,0.004533364,0.0001157209,0.00001965493,0.00004813344,0.0005057509,0.00002539417,0.00672266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001379997,"threshold_uncertainty_score":0.004616559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003950160064581259,"score_gpt":0.2159408062698448,"score_spread":0.2119906462052635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}