{"id":"W4407574412","doi":"10.1007/s40263-025-01164-w","title":"Treatment De-escalation in Relapsing-Remitting Multiple Sclerosis: An Observational Study","year":2025,"lang":"en","type":"article","venue":"CNS Drugs","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Jerome; Université de Montréal; Centre intégré de santé et de services sociaux de Chaudière-Appalaches","funders":"National Health and Medical Research Council; EMD Serono; Schweizerische Multiple Sklerose Gesellschaft; Università di Catania; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Multiple Sclerosis Australia; Medical Research Council; Biogen; Celgene; Sanofi Genzyme; University of Melbourne; F. Hoffmann-La Roche; Monash University; Alexion Pharmaceuticals; Teva Pharmaceutical Industries; Bayer HealthCare; Sanofi; Atara Biotherapeutics; Universität Basel; Bristol-Myers Squibb; Multiple Sclerosis Society; European Committee for Treatment and Research in Multiple Sclerosis; National Science Foundation","keywords":"Relapsing remitting; Multiple sclerosis; Observational study; Medicine; Psychopharmacology; Neurology; Psychology; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005369295,0.0003251254,0.0007379327,0.0007279588,0.0005979429,0.0007252843,0.0008452986,0.0006665828,0.0007639341],"category_scores_gemma":[0.01102206,0.000447029,0.001154512,0.002088075,0.0004284747,0.0005687742,0.0007637438,0.001070808,0.0001451746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006616675,"about_ca_system_score_gemma":0.0009601022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004087348,"about_ca_topic_score_gemma":0.003825599,"domain_scores_codex":[0.9935871,0.0034848,0.0008544573,0.001139652,0.0006390432,0.00029494],"domain_scores_gemma":[0.9834857,0.002624103,0.01074038,0.001653813,0.0006765353,0.000819497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006047384,0.0001116964,0.9975337,0.00003322428,0.0005002668,0.00005322416,0.00008272462,0.00005537716,0.00008365721,0.00002512104,0.0001310957,0.0007852163],"study_design_scores_gemma":[0.0002162097,0.0005767514,0.9971589,0.00003727965,0.0003737288,0.0003871271,0.0002441736,0.0005608127,0.00005899946,0.00004840798,0.0003271544,0.00001049447],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989977,0.0003954309,0.000153137,0.00003836697,0.000005785138,0.00002733833,0.0002858162,0.000001959566,0.00009435453],"genre_scores_gemma":[0.9989643,0.0001664746,0.0001837529,0.00006551129,0.00001129272,0.00003800161,0.000535935,0.000001504397,0.00003317343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005369295,"threshold_uncertainty_score":0.02839589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2396049534470394,"score_gpt":0.3990076854640167,"score_spread":0.1594027320169773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}