{"id":"W4407574412","doi":"10.1007/s40263-025-01164-w","title":"Treatment De-escalation in Relapsing-Remitting Multiple Sclerosis: An Observational Study","year":2025,"lang":"en","type":"article","venue":"CNS Drugs","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Jerome; Université de Montréal; Centre intégré de santé et de services sociaux de Chaudière-Appalaches","funders":"National Health and Medical Research Council; EMD Serono; Schweizerische Multiple Sklerose Gesellschaft; Università di Catania; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Multiple Sclerosis Australia; Medical Research Council; Biogen; Celgene; Sanofi Genzyme; University of Melbourne; F. Hoffmann-La Roche; Monash University; Alexion Pharmaceuticals; Teva Pharmaceutical Industries; Bayer HealthCare; Sanofi; Atara Biotherapeutics; Universität Basel; Bristol-Myers Squibb; Multiple Sclerosis Society; European Committee for Treatment and Research in Multiple Sclerosis; National Science Foundation","keywords":"Relapsing remitting; Multiple sclerosis; Observational study; Medicine; Psychopharmacology; Neurology; Psychology; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005221803,0.0001618782,0.0002981938,0.000259683,0.0001914585,0.0000368619,0.0000909919,0.00006754038,0.00002610788],"category_scores_gemma":[0.0009588444,0.0001411246,0.00006534885,0.0005093855,0.00005767347,0.0001524507,0.00007023612,0.0001776625,0.00001295298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000831462,"about_ca_system_score_gemma":0.000237744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007349316,"about_ca_topic_score_gemma":0.0004965786,"domain_scores_codex":[0.998428,0.0001644125,0.0003629023,0.0003724398,0.0003294463,0.000342798],"domain_scores_gemma":[0.9989944,0.0003709815,0.00005387036,0.0003339719,0.0001444086,0.000102359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001661817,0.00153674,0.944666,0.00002823354,0.00008782129,0.00000470666,0.00574256,0.0001697917,0.006642426,0.00004794467,0.000179165,0.04072845],"study_design_scores_gemma":[0.005375328,0.0003209239,0.9719432,0.0002737717,0.00004367011,5.876846e-7,0.005475692,0.01530878,0.0008102612,0.00003619445,0.0003174227,0.00009417971],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950013,0.0001752374,0.000109932,0.001474729,0.00009425976,0.001137624,0.00000616734,0.00008765986,0.001913087],"genre_scores_gemma":[0.9968225,0.00009819214,0.001494485,0.0001508604,0.00009608033,0.0002992876,0.00004096481,0.00001619331,0.0009814755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04063427,"threshold_uncertainty_score":0.5754894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2396049534470394,"score_gpt":0.3990076854640167,"score_spread":0.1594027320169773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}