{"id":"W4407576956","doi":"10.1117/12.3046835","title":"Bundle-wise functional connectivity density and fractional amplitude of low-frequency fluctuations decrease in white matter in preclinical Alzheimer's disease and are associated with A[beta] levels and cognition","year":2025,"lang":"en","type":"article","venue":"","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Institutes of Health; Genentech; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Vanderbilt University; University of Southern California; Vanderbilt Memory and Alzheimer's Center; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; National Institute of Mental Health; Novartis Pharmaceuticals Corporation; National Institute on Aging; Alzheimer's Association","keywords":"BETA (programming language); Amplitude; Cognition; White matter; Physics; Disease; Neuroscience; Medicine; Psychology; Computer science; Quantum mechanics; Internal medicine; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004578865,0.0001967987,0.0002165717,0.0007205214,0.0001867959,0.0002358318,0.0001485939,0.0001894212,0.001070826],"category_scores_gemma":[0.00169444,0.000151712,0.0001611891,0.0004162083,0.0002593068,0.0003113404,0.0002566524,0.0001805163,0.0001009796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001047434,"about_ca_system_score_gemma":0.00009105533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001545367,"about_ca_topic_score_gemma":0.002902018,"domain_scores_codex":[0.9998413,0.00003296768,0.00001854817,0.0000541425,0.00003366709,0.00001929207],"domain_scores_gemma":[0.999438,0.00009974677,0.0002727431,0.00007723705,0.00005533281,0.00005706819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001862185,0.0001830876,0.8348742,0.0001158833,0.0005442277,0.0004561917,0.001012009,0.001913766,0.1230117,0.0005106774,0.000883263,0.03463287],"study_design_scores_gemma":[0.000005878277,0.0001046923,0.9962608,0.000002249315,0.00002356326,0.0003062655,0.0000438232,0.001336143,0.001402757,0.0003540948,0.0001555883,0.000004175421],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987721,0.00005529314,0.0008530448,0.00001048924,0.000001455204,0.000003647437,0.0001378688,0.00001322021,0.0001528222],"genre_scores_gemma":[0.9987633,0.00003295054,0.0008321562,0.000005329691,0.000003632946,0.000008355095,0.0002319706,0.000005312306,0.0001169354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001545367,"threshold_uncertainty_score":0.003582299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05801809130241514,"score_gpt":0.2967350313882377,"score_spread":0.2387169400858226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}