{"id":"W4407577249","doi":"10.1093/braincomms/fcaf068","title":"Neuronal and glial dysfunction, white matter hyperintensities and cognition in ageing and Alzheimer’s disease","year":2024,"lang":"en","type":"article","venue":"Brain Communications","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Takeda Pharmaceutical Company; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Eisai Canada; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; Biogen; BioClinica; AbbVie Canada; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; F. Hoffmann-La Roche; Alzheimer's Drug Discovery Foundation; Merck; Fujirebio Europe; Bristol-Myers Squibb Canada; Alzheimer's Association; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Hyperintensity; Neuroscience; White matter; Cognition; Disease; Alzheimer's disease; Brain aging; Medicine; Psychology; Pathology; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001655179,0.00007078203,0.00008138188,0.0001395174,0.0001230268,0.0001082028,0.00003949363,0.00002083762,0.00009641362],"category_scores_gemma":[0.00006656551,0.00006725878,0.00001519691,0.00009211808,0.0002533992,0.0001449574,0.0001879102,0.0001700374,0.00001451106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008287649,"about_ca_system_score_gemma":0.00003672705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000291539,"about_ca_topic_score_gemma":0.00004936596,"domain_scores_codex":[0.9994399,0.0000892952,0.0001129206,0.000155115,0.00009373174,0.0001090619],"domain_scores_gemma":[0.9994134,0.0002140397,0.00001015911,0.0002052546,0.00005731544,0.00009986392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002490936,0.000203352,0.9442465,0.0002989878,0.0001516396,0.000114902,0.001410888,3.452655e-7,0.001962464,0.001733219,0.006484878,0.04314375],"study_design_scores_gemma":[0.0005040636,0.00005880733,0.9892189,0.0001935298,0.0001150452,0.00005885862,0.000457832,0.002062853,0.00001682646,0.0007564244,0.00649097,0.00006588149],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9262403,0.00516806,0.00009129915,0.06386402,0.00003255751,0.0003234597,0.00002416782,0.00003963606,0.00421648],"genre_scores_gemma":[0.9960325,0.0009717516,0.0001611837,0.001973779,0.0000277977,0.00006367436,0.00007678239,0.00001111205,0.0006814633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06979213,"threshold_uncertainty_score":0.2742734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03782560022723619,"score_gpt":0.3240512920545767,"score_spread":0.2862256918273405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}