{"id":"W4407577249","doi":"10.1093/braincomms/fcaf068","title":"Neuronal and glial dysfunction, white matter hyperintensities and cognition in ageing and Alzheimer’s disease","year":2024,"lang":"en","type":"article","venue":"Brain Communications","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Takeda Pharmaceutical Company; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Eisai Canada; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; Biogen; BioClinica; AbbVie Canada; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; F. Hoffmann-La Roche; Alzheimer's Drug Discovery Foundation; Merck; Fujirebio Europe; Bristol-Myers Squibb Canada; Alzheimer's Association; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Hyperintensity; Neuroscience; White matter; Cognition; Disease; Alzheimer's disease; Brain aging; Medicine; Psychology; Pathology; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008180595,0.0003089648,0.000258707,0.0004733065,0.000321488,0.0004765279,0.0001922995,0.0003975678,0.00083752],"category_scores_gemma":[0.001580782,0.0002712146,0.0002585077,0.0004343495,0.0001984039,0.0004596212,0.0003326265,0.0004320829,0.0001518234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000112908,"about_ca_system_score_gemma":0.0001360815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002578298,"about_ca_topic_score_gemma":0.004000152,"domain_scores_codex":[0.9998222,0.00006062914,0.00002493334,0.00004277783,0.00002810623,0.00002132759],"domain_scores_gemma":[0.9991916,0.0001334106,0.0003817754,0.00005208891,0.00009522228,0.0001460147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001977614,0.00006774259,0.9982058,0.00001129931,0.000101657,0.00004977678,0.00008754287,0.0000233084,0.0003890373,0.00001106671,0.00003164373,0.0008232896],"study_design_scores_gemma":[0.000003101107,0.0000916585,0.9995908,0.000002368219,0.0000186233,0.0001018386,0.00005863694,0.00004528291,0.00003585923,0.00001945602,0.00003122104,0.000001190747],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994915,0.0002569704,0.0000315019,0.00001403062,0.000003452599,0.000002684429,0.00007358556,9.514128e-7,0.0001252885],"genre_scores_gemma":[0.9996215,0.00007559669,0.00006747842,0.00001636194,0.00000628276,0.000002911244,0.00009184674,4.643934e-7,0.0001174551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002578298,"threshold_uncertainty_score":0.005126595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03782560022723619,"score_gpt":0.3240512920545767,"score_spread":0.2862256918273405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}