{"id":"W4407579196","doi":"10.1101/gr.279203.124","title":"Genetic regulation of nascent RNA maturation revealed by direct RNA nanopore sequencing","year":2025,"lang":"en","type":"article","venue":"Genome Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health and Social Services Centre University Institute of Geriatrics of Sherbrooke; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; Canadian Institutes of Health Research; National Institutes of Health; Université de Sherbrooke","keywords":"Biology; Genetics; RNA splicing; Polyadenylation; Intron; Alternative splicing; Allele; RNA; Gene; Exon","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001862009,0.0001475209,0.0001643935,0.0001795685,0.0001119523,0.0002548477,0.0001153895,0.0002439766,0.0004255853],"category_scores_gemma":[0.0005707708,0.0001322847,0.0001621982,0.000134167,0.0001778253,0.0001225573,0.0001682366,0.0002467463,0.0002012038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001320118,"about_ca_system_score_gemma":0.00007631184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000371197,"about_ca_topic_score_gemma":0.00088333,"domain_scores_codex":[0.9997935,0.00002856566,0.00001444766,0.00009028263,0.00005033426,0.00002292402],"domain_scores_gemma":[0.9995425,0.0002207432,0.0001155288,0.00004985332,0.00004708099,0.0000242924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004251492,0.000006019671,0.003128515,0.00002049603,0.000008032956,0.00005348028,0.00002781079,0.0001213783,0.9946408,0.00006246875,0.00002040375,0.001867951],"study_design_scores_gemma":[0.000006599264,0.0001805455,0.08144709,0.00000851078,0.00003681866,0.0005819367,0.00007068054,0.005946275,0.9098423,0.000401,0.001461189,0.0000170825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817648,0.0006036689,0.01591115,0.00003657725,0.00001301013,0.00002470203,0.0006893429,0.0001222886,0.0008344243],"genre_scores_gemma":[0.9843175,0.0003153717,0.01402152,0.00006623296,0.000005891576,0.00003661759,0.0005301501,0.00003156231,0.0006751727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004255853,"threshold_uncertainty_score":0.001423717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0229968648329909,"score_gpt":0.3255679939857459,"score_spread":0.302571129152755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}