{"id":"W4407579196","doi":"10.1101/gr.279203.124","title":"Genetic regulation of nascent RNA maturation revealed by direct RNA nanopore sequencing","year":2025,"lang":"en","type":"article","venue":"Genome Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health and Social Services Centre University Institute of Geriatrics of Sherbrooke; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; Canadian Institutes of Health Research; National Institutes of Health; Université de Sherbrooke","keywords":"Biology; Genetics; RNA splicing; Polyadenylation; Intron; Alternative splicing; Allele; RNA; Gene; Exon","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001119001,0.0001087082,0.0001580259,0.0002088718,0.0001909059,0.00004248424,0.0002812733,0.000142614,0.00003896749],"category_scores_gemma":[0.0002827369,0.0001036579,0.00006708643,0.0004564422,0.0001252954,0.000005766701,0.0001901887,0.0001930311,0.00001144292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001442646,"about_ca_system_score_gemma":0.0003580591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001653467,"about_ca_topic_score_gemma":0.00003126378,"domain_scores_codex":[0.998089,0.0002958405,0.0002881937,0.0003760985,0.0004865045,0.0004643432],"domain_scores_gemma":[0.998912,0.00003808691,0.00005717728,0.0004676807,0.0004284637,0.00009657515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00014119,0.00002300257,0.0005228126,0.0001104674,0.00004086632,0.000002165445,0.00003464328,0.0001088407,0.9900126,0.00004557093,0.003998229,0.004959586],"study_design_scores_gemma":[0.0004595144,0.0002496198,0.02209378,0.00007481576,0.000006764758,0.000002850707,0.0001359593,0.0006293977,0.965848,0.0002069716,0.01015586,0.0001364084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872308,0.004047061,0.0008400186,0.0002958105,0.00004427339,0.0004415677,0.00001928998,0.000009239982,0.007071909],"genre_scores_gemma":[0.9811434,0.0009544702,0.0005944981,0.00002722897,0.00009321864,0.00003725531,0.0001358838,0.00001609459,0.01699796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02416457,"threshold_uncertainty_score":0.4227047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0229968648329909,"score_gpt":0.3255679939857459,"score_spread":0.302571129152755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}