{"id":"W4407592273","doi":"10.1186/s12981-025-00713-z","title":"Drug transporter mRNA expression and genital inflammation in South African women on oral pre-exposure prophylaxis (PrEP)","year":2025,"lang":"en","type":"article","venue":"AIDS Research and Therapy","topic":"HIV/AIDS Research and Interventions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"European and Developing Countries Clinical Trials Partnership; Fogarty International Center; Inyuvesi Yakwazulu-Natali; Department of Science and Technology, Ministry of Science and Technology, India; South African Medical Research Council; African Academy of Sciences; Fonds National de la Recherche Luxembourg; Poliomyelitis Research Foundation; Medical Research Council; National Research Foundation; United States Agency for International Development; FHI 360; Government of the United Kingdom","keywords":"Medicine; Drug; Pre-exposure prophylaxis; Inflammation; Transporter; Pharmacology; Traditional medicine; Physiology; Internal medicine; Immunology; Gene; Human immunodeficiency virus (HIV); Genetics; Men who have sex with men; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001174853,0.0001099558,0.0001235626,0.0003299284,0.000187475,0.0002550254,0.00005530124,0.0001965931,0.002005016],"category_scores_gemma":[0.0004663579,0.0001594316,0.00008901147,0.0003305833,0.0001929878,0.0001406002,0.000134529,0.0001868757,0.0001504041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001495207,"about_ca_system_score_gemma":0.0001000047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001364259,"about_ca_topic_score_gemma":0.001439718,"domain_scores_codex":[0.9999236,0.00001913818,0.000004684305,0.00002256755,0.00001169677,0.00001838014],"domain_scores_gemma":[0.9998697,0.0000368115,0.00005644157,0.000008502287,0.00001502184,0.00001345299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001819487,0.0001875974,0.9064477,0.0001689399,0.00003712724,0.0008763344,0.001680387,0.0001064444,0.07275359,0.0000769805,0.000202237,0.01564314],"study_design_scores_gemma":[0.000007764254,0.0005887828,0.9943148,0.00001265072,0.00002055319,0.0008395365,0.0007044537,0.0001162528,0.002848767,0.00003118583,0.0005114826,0.000003661165],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991266,0.0003948943,0.00005405305,0.00002146218,0.000002488003,0.000007658124,0.0001456396,0.000001691556,0.0002455286],"genre_scores_gemma":[0.9989104,0.0003078381,0.0001641919,0.00002246126,0.000004331927,0.00002346732,0.00009976135,0.00000119833,0.0004663325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002005016,"threshold_uncertainty_score":0.00670743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02546161525325878,"score_gpt":0.3430771662654061,"score_spread":0.3176155510121473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}