{"id":"W4407592364","doi":"10.1101/2025.02.10.637468","title":"Helix-8 and Carboxyl Terminal Tail Regulation of Proteinase Activated Receptor-4 (PAR4) signalling","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"G protein-coupled receptor; Intracellular; Phosphorylation; Arrestin; Cell biology; Receptor; Transmembrane domain; Signal transduction; G protein; Helix (gastropod); Cell signaling; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000985581,0.0001766454,0.0001239646,0.00009672843,0.0001247717,0.0001831,0.0001167549,0.000236917,0.001822057],"category_scores_gemma":[0.00008091901,0.00007645606,0.0001546498,0.00006521813,0.0001537285,0.0001352489,0.0001358275,0.0002913917,0.0008010639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002540801,"about_ca_system_score_gemma":0.00009699694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003822609,"about_ca_topic_score_gemma":0.000369442,"domain_scores_codex":[0.9999237,0.0000193176,0.000003021996,0.00001299284,0.00001685221,0.00002419224],"domain_scores_gemma":[0.9999607,0.000007812973,0.00001275696,0.000003534341,0.000004164706,0.00001103122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000149237,0.000009476482,0.0003971488,0.00001694767,0.000003551729,0.00009898595,0.00000715274,0.0002446629,0.9979982,0.0001967463,0.00007879184,0.0007990577],"study_design_scores_gemma":[0.00004306657,0.0001380347,0.0111561,0.00000396114,0.000008880156,0.0002626552,0.00003124497,0.007088776,0.9782665,0.0002419252,0.002752442,0.000006534796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948794,0.0004928418,0.002572294,0.0001084846,0.00001994713,0.00001123567,0.0001987984,0.00006033741,0.001656679],"genre_scores_gemma":[0.9955524,0.0002180841,0.001754828,0.00003486009,0.00001019015,0.000009827293,0.0002511464,0.00001443341,0.002154115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001822057,"threshold_uncertainty_score":0.00609535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009357324143448252,"score_gpt":0.2132379648013497,"score_spread":0.2038806406579014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}