{"id":"W4407594881","doi":"10.1021/acsnano.4c14735","title":"Multilayer Adjuvanted Influenza Protein Nanoparticles Improve Intranasal Delivery and Antigen-Specific Immunity","year":2025,"lang":"en","type":"article","venue":"ACS Nano","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Division of Electrical, Communications and Cyber Systems; National Institute of Allergy and Infectious Diseases; National Science Foundation","keywords":"Nasal administration; Antigen; Immunity; Virology; Nanoparticle; Medicine; Immunology; Immune system; Nanotechnology; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009924571,0.0003436251,0.0001753706,0.0001278173,0.00005549395,0.0001504322,0.0001063641,0.0003019667,0.000441181],"category_scores_gemma":[0.0001122968,0.000115875,0.0001806918,0.00005280066,0.00008973588,0.0001802767,0.0001877242,0.0002544939,0.0001802233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001638836,"about_ca_system_score_gemma":0.0001276972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004263707,"about_ca_topic_score_gemma":0.0007888585,"domain_scores_codex":[0.9999343,0.000009774374,0.000005601512,0.00001344146,0.00001597874,0.00002088418],"domain_scores_gemma":[0.9999574,0.000005779302,0.00001521656,0.000002961092,0.000009720284,0.00000883326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002288907,0.0000158841,0.00005173064,0.00002335786,0.000003015461,0.000009793312,0.000003808124,0.00008966435,0.9983447,0.00002178403,0.00002854533,0.001384864],"study_design_scores_gemma":[0.00001152072,0.0004929658,0.001319249,0.000005069974,0.00002172804,0.00006337936,0.000007225767,0.002282298,0.9942043,0.00002174925,0.001566032,0.000004497848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859917,0.003133664,0.00869586,0.0001401475,0.00006365286,0.00004899078,0.0000953219,0.0001688143,0.001661755],"genre_scores_gemma":[0.9927088,0.0006607377,0.004886136,0.00008356463,0.00001247831,0.00001804326,0.00006766909,0.00001318231,0.001549427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000441181,"threshold_uncertainty_score":0.00147593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04531745977700171,"score_gpt":0.3408947206602819,"score_spread":0.2955772608832802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}