{"id":"W4407594881","doi":"10.1021/acsnano.4c14735","title":"Multilayer Adjuvanted Influenza Protein Nanoparticles Improve Intranasal Delivery and Antigen-Specific Immunity","year":2025,"lang":"en","type":"article","venue":"ACS Nano","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Division of Electrical, Communications and Cyber Systems; National Institute of Allergy and Infectious Diseases; National Science Foundation","keywords":"Nasal administration; Antigen; Immunity; Virology; Nanoparticle; Medicine; Immunology; Immune system; Nanotechnology; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003803367,0.000244268,0.000413808,0.0002546965,0.0003327942,0.00005659302,0.0001648591,0.0001355527,0.00004168727],"category_scores_gemma":[0.0003950546,0.000203312,0.00006833379,0.0004675178,0.0003990975,0.0001857991,0.0003292635,0.000395654,0.00006088278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001028999,"about_ca_system_score_gemma":0.0001756115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002579726,"about_ca_topic_score_gemma":0.00003510293,"domain_scores_codex":[0.9982487,0.0001108966,0.0003994984,0.0003750956,0.0003231922,0.0005426078],"domain_scores_gemma":[0.9987634,0.0001357654,0.00006257588,0.0005190412,0.0003860526,0.0001330943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001004199,0.0001644423,0.01255235,0.0001326635,0.0002012356,0.00003803026,0.0004583402,9.203961e-7,0.9505883,0.0003323014,0.00119571,0.03333148],"study_design_scores_gemma":[0.003808501,0.0002723684,0.08179587,0.0002883193,0.00003034634,0.000005051468,0.000395849,0.0000796288,0.8463985,0.000116939,0.06660207,0.0002065279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876637,0.009359923,0.00002219253,0.0006196615,0.00009859874,0.001148165,0.0000204027,0.000124396,0.0009429503],"genre_scores_gemma":[0.9957971,0.001617413,0.0006780358,0.001197268,0.00005660368,0.0001102432,0.000004590984,0.0000237633,0.0005149557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1041898,"threshold_uncertainty_score":0.8290824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04531745977700171,"score_gpt":0.3408947206602819,"score_spread":0.2955772608832802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}