{"id":"W4407595270","doi":"10.1007/s12672-025-01893-w","title":"Anti-tumor potential of Harmine and its derivatives: recent trends and advancements","year":2025,"lang":"en","type":"review","venue":"Discover Oncology","topic":"Synthesis and bioactivity of alkaloids","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"VIT University","keywords":"Harmine; Peganum harmala; Alkaloid; Pharmacology; Chemistry; Biology; Traditional medicine; Medicine; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002754944,0.0005007619,0.0006717815,0.001497137,0.0001913233,0.0007761916,0.0004878757,0.0005355521,0.002802768],"category_scores_gemma":[0.0002976473,0.0002299242,0.00036311,0.001194311,0.00026314,0.0008505807,0.0003898612,0.001098927,0.001067928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003554185,"about_ca_system_score_gemma":0.000521266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004803522,"about_ca_topic_score_gemma":0.0009935366,"domain_scores_codex":[0.999917,0.0000112309,0.00001090512,0.00002025427,0.00003105247,0.000009556722],"domain_scores_gemma":[0.9998838,0.00005304384,0.00002064419,0.000003860308,0.00002703737,0.00001159635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001175102,0.000162432,0.0002542874,0.02673683,0.000102637,0.0003906386,0.0001054726,0.0008220082,0.01515153,0.005744718,0.01087436,0.9395377],"study_design_scores_gemma":[0.00001954647,0.0002365223,0.0007973764,0.001456977,0.0001254145,0.001523198,0.00006025963,0.0002299521,0.004001779,0.001818664,0.9897063,0.00002405591],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005144972,0.9978047,0.0001815627,0.0001361219,0.00007182963,0.000004493562,0.00001895976,0.000007870999,0.001259843],"genre_scores_gemma":[0.00220827,0.9967488,0.000245831,0.0001000484,0.00008481323,0.000005026458,0.00002846759,0.000001715202,0.0005770919],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002802768,"threshold_uncertainty_score":0.009376168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02365074793306205,"score_gpt":0.3473900768059235,"score_spread":0.3237393288728614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}