{"id":"W4407603251","doi":"10.1038/s41467-025-56895-7","title":"Unmasking the halide effect in diastereoselective Grignard reactions applied to C4´ modified nucleoside synthesis","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Coordination Chemistry and Organometallics","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Glycomics Network; Alliance de recherche numérique du Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Québec Consortium for Drug Discovery","keywords":"Halide; Nucleoside; Grignard reaction; Chemistry; Combinatorial chemistry; Nucleoside analogue; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006079908,0.0004480793,0.0002696416,0.0001700207,0.000206896,0.0003359115,0.0004445259,0.0004342721,0.001238567],"category_scores_gemma":[0.0007718557,0.0002566651,0.0002054879,0.0001438574,0.000501766,0.0005148071,0.0006132456,0.0008988301,0.0004830621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003236552,"about_ca_system_score_gemma":0.0003754799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00061773,"about_ca_topic_score_gemma":0.001750108,"domain_scores_codex":[0.9996879,0.00005827324,0.0000258787,0.00005298588,0.00009018876,0.00008480526],"domain_scores_gemma":[0.9997805,0.00008404579,0.00004900482,0.00003420905,0.0000256875,0.00002659462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000199433,0.00004171299,0.00029811,0.0002751205,0.00002429767,0.0004589044,0.0002975476,0.0007050543,0.9841114,0.00242386,0.0002624807,0.010902],"study_design_scores_gemma":[0.00001299308,0.0002322028,0.0002058682,0.00000744929,0.000007654237,0.0001555446,0.00001592647,0.000616434,0.9957836,0.000165767,0.002783452,0.00001322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9477345,0.004199894,0.0305927,0.0007232309,0.0001903385,0.0002289065,0.0001893813,0.0005700947,0.01557091],"genre_scores_gemma":[0.9887335,0.001745063,0.007857722,0.0001416225,0.00002469166,0.00003793487,0.00006361517,0.00004098379,0.001354851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001238567,"threshold_uncertainty_score":0.004143357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01206986970397222,"score_gpt":0.2867709593819811,"score_spread":0.2747010896780089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}