{"id":"W4407621635","doi":"10.1016/j.ijgc.2024.100432","title":"Randomized Study Evaluating Optimal Dose, Efficacy And Safety Of E7386 + Lenvatinib Versus Treatment Of Physicians’ Choice In Advanced/Recurrent Endometrial Carcinoma Previously Treated With Anti-PD-(L)1 Immunotherapy","year":2025,"lang":"en","type":"article","venue":"International Journal of Gynecological Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre","funders":"Eisai","keywords":"Medicine; Lenvatinib; Immunotherapy; Oncology; Internal medicine; Randomized controlled trial; Gynecology; Sorafenib; Cancer; Hepatocellular carcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002993361,0.001291203,0.00343419,0.0004393258,0.0004316496,0.001232869,0.0009785728,0.001992022,0.006515893],"category_scores_gemma":[0.004097724,0.0009021285,0.003107492,0.0005183487,0.001792297,0.001309698,0.0006619276,0.003865206,0.0008123535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001675632,"about_ca_system_score_gemma":0.001393447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001784094,"about_ca_topic_score_gemma":0.003269539,"domain_scores_codex":[0.9976634,0.00145771,0.0001347412,0.0003494425,0.0001208715,0.0002739259],"domain_scores_gemma":[0.9967968,0.001309825,0.0007194023,0.0003412546,0.0001608887,0.000671825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.991899,0.002292363,0.0005137437,0.00008975899,0.0009007739,0.00001352422,0.00001042266,0.0002468335,0.0003522766,0.0000479591,0.0001630424,0.003470315],"study_design_scores_gemma":[0.9266533,0.06817082,0.002171498,0.00002564022,0.001260361,0.00002257164,0.00001922326,0.0007294133,0.0002041683,0.0002271707,0.0004997922,0.00001596025],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988833,0.003923918,0.0007769506,0.0007011992,0.0008333675,0.002015998,0.0007735729,0.00006026603,0.002081727],"genre_scores_gemma":[0.9932631,0.0009023391,0.0009777071,0.0009745694,0.0004141707,0.001149284,0.0006264544,0.00001545235,0.001677004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006515893,"threshold_uncertainty_score":0.02179784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04684456063379593,"score_gpt":0.3959338950705721,"score_spread":0.3490893344367761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}