{"id":"W4407623092","doi":"10.3390/vaccines13020199","title":"Novel sACE2-Anti-CD16VHH Fusion Protein Surreptitiously Inhibits SARS-CoV-2 Variant Spike Proteins and Macrophage Cytokines, and Activates Natural Killer Cell Cytotoxicity","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Harvard Stem Cell Institute; Semnan University of Medical Sciences and Health Services; Semnan University; Natural Sciences and Engineering Research Council of Canada; Queen's University","keywords":"Cytotoxicity; Spike (software development); Fusion protein; Spike Protein; Virology; Biology; Coronavirus disease 2019 (COVID-19); Medicine; Genetics; Gene; Computer science; In vitro; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004114568,0.0004810634,0.0006761396,0.0004943574,0.0003036331,0.0001617421,0.0001943791,0.0002846745,0.00001183291],"category_scores_gemma":[0.0003383473,0.0003737342,0.000113049,0.0007931117,0.0001123782,0.0002737311,0.0004372126,0.0006370193,0.00001987868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000102639,"about_ca_system_score_gemma":0.0003022083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00120172,"about_ca_topic_score_gemma":0.0002492485,"domain_scores_codex":[0.9974833,0.0000847986,0.0004806481,0.0008730778,0.0004427747,0.000635448],"domain_scores_gemma":[0.9988772,0.0001265051,0.0001375504,0.0005146348,0.0002729542,0.0000711758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007725082,0.0004351878,0.01204649,0.0009535826,0.00007246796,0.0001559194,0.0001511055,1.488197e-7,0.9831943,0.000161921,0.0006024637,0.001453938],"study_design_scores_gemma":[0.004816332,0.0002887449,0.03572743,0.0005472769,0.00006823178,0.0001691945,0.0000607598,0.0004210642,0.9481246,0.0001502584,0.009267272,0.0003588144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924225,0.001638377,0.000370242,0.001496036,0.0002216045,0.002744136,0.00002324881,0.0001833565,0.0009004545],"genre_scores_gemma":[0.9918279,0.00004324937,0.0009437789,0.006045564,0.0002150425,0.0001958803,0.00001189979,0.00005550014,0.0006611667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03506965,"threshold_uncertainty_score":0.9998714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870711702492357,"score_gpt":0.2947767314903376,"score_spread":0.2760696144654141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}