{"id":"W4407623092","doi":"10.3390/vaccines13020199","title":"Novel sACE2-Anti-CD16VHH Fusion Protein Surreptitiously Inhibits SARS-CoV-2 Variant Spike Proteins and Macrophage Cytokines, and Activates Natural Killer Cell Cytotoxicity","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Harvard Stem Cell Institute; Semnan University of Medical Sciences and Health Services; Semnan University; Natural Sciences and Engineering Research Council of Canada; Queen's University","keywords":"Cytotoxicity; Spike (software development); Fusion protein; Spike Protein; Virology; Biology; Coronavirus disease 2019 (COVID-19); Medicine; Genetics; Gene; Computer science; In vitro; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000128655,0.0003450801,0.0003085027,0.0001035261,0.00009891607,0.0001822164,0.0002030547,0.0003049812,0.001064278],"category_scores_gemma":[0.00007922631,0.00009901232,0.00024388,0.00008530403,0.0001948386,0.0001729613,0.0001433249,0.0005556173,0.0004021722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002914706,"about_ca_system_score_gemma":0.0001647337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002379332,"about_ca_topic_score_gemma":0.0003140392,"domain_scores_codex":[0.9998807,0.00001605992,0.000009849943,0.00002880298,0.00003562009,0.00002890877],"domain_scores_gemma":[0.9999429,0.00001001072,0.00001555798,0.000008449767,0.000007290889,0.00001573503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007700932,0.00003822183,0.0000778204,0.00002285196,0.000005601183,0.00002376686,0.00000428158,0.00007098188,0.9989995,0.00005546832,0.00005442364,0.0005700784],"study_design_scores_gemma":[0.00004640959,0.0004216933,0.001058608,0.000002281828,0.00001119216,0.00035547,0.000005305501,0.0009690572,0.9938604,0.00001780429,0.003249074,0.000002848988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931272,0.001354311,0.003827374,0.0001162147,0.00006529517,0.00003751947,0.0002600288,0.00008966424,0.001122392],"genre_scores_gemma":[0.991519,0.0004815726,0.003540733,0.00007934488,0.00003402559,0.00003330024,0.001293025,0.00001738411,0.003001622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001064278,"threshold_uncertainty_score":0.003560364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870711702492357,"score_gpt":0.2947767314903376,"score_spread":0.2760696144654141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}