{"id":"W4407624903","doi":"10.21203/rs.3.rs-6025759/v1","title":"A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations ","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Population Health Research Institute; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Institutes of Health; National Heart, Lung, and Blood Institute; National Institute for Health and Care Research","keywords":"Genome-wide association study; Biology; Genetics; Population; Candidate gene; Copy-number variation; Druggability; Gene; Genetic association; Single-nucleotide polymorphism; Genome; Medicine; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002425993,0.0006835418,0.0008929201,0.0007560275,0.001302976,0.0009791665,0.0007362029,0.001000855,0.001703346],"category_scores_gemma":[0.004301941,0.000664937,0.001114287,0.002086628,0.0006577169,0.0004034304,0.001002036,0.0009227422,0.0003553153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002413278,"about_ca_system_score_gemma":0.0005200962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01357675,"about_ca_topic_score_gemma":0.01452279,"domain_scores_codex":[0.9979416,0.0009302843,0.0001083177,0.0007134078,0.0001473825,0.0001589783],"domain_scores_gemma":[0.997879,0.0009220861,0.0002065156,0.0005825515,0.0001614643,0.000248415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001975235,0.0001935191,0.979294,0.00004506304,0.002184326,0.000841153,0.0009169601,0.0001994608,0.008524577,0.0001318854,0.0007852793,0.004908436],"study_design_scores_gemma":[0.0001068254,0.0001635056,0.9977622,0.00000565318,0.0005397198,0.0003105819,0.0002571185,0.0001858374,0.0001924003,0.00008117885,0.0003839222,0.00001100235],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980432,0.0001378696,0.0006499328,0.00005557712,0.00001261901,0.00001281558,0.0008766816,0.00001135454,0.0002000262],"genre_scores_gemma":[0.9977648,0.00007647806,0.0007564073,0.00005881969,0.00001584851,0.00001918046,0.0009414956,0.00001346626,0.0003535009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01357675,"threshold_uncertainty_score":0.02699542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04569767498556719,"score_gpt":0.3917864871588352,"score_spread":0.346088812173268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}