{"id":"W4407626569","doi":"10.1016/j.isci.2025.112042","title":"Actin fenestrae amplify the membrane response to hypertonic stress in osmosensory neurons","year":2025,"lang":"en","type":"article","venue":"iScience","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Foundation for Innovation; McGill University Health Centre","keywords":"Actin; Biophysics; Chemistry; Cell biology; Tonicity; Membrane; Neuroscience; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006123999,0.000143755,0.000139776,0.0002400865,0.0003136625,0.0001260406,0.0007819805,0.00005682054,0.00003158758],"category_scores_gemma":[0.002135445,0.0001083739,0.00004307333,0.001763916,0.0003225461,0.0001753942,0.0001693167,0.0003156773,0.000177602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006857745,"about_ca_system_score_gemma":0.0003029335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006622184,"about_ca_topic_score_gemma":0.0001114998,"domain_scores_codex":[0.9979958,0.0003459007,0.0002117601,0.0006175325,0.0003108614,0.0005181429],"domain_scores_gemma":[0.9978795,0.001319136,0.00004070836,0.0006187361,0.00001670418,0.0001252057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001288612,0.00004927447,0.001205785,0.00000574652,3.940314e-7,0.00008991567,0.000567414,0.0007924865,0.9870766,0.006004102,0.0002002732,0.003879089],"study_design_scores_gemma":[0.0002588802,0.00004411868,0.158636,0.00005410847,0.000003249169,0.00005155823,0.000234441,0.000322386,0.8030603,0.0001053828,0.03707173,0.0001578986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828191,0.0001086917,0.00003781142,0.01072709,0.0005971169,0.0003345768,0.00001634308,0.00006075634,0.005298457],"genre_scores_gemma":[0.9895916,0.00002615289,0.00003462606,0.004440412,0.00002340591,0.00003427319,1.460206e-7,0.000008903942,0.005840489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1840164,"threshold_uncertainty_score":0.441936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03058451163485536,"score_gpt":0.2903689716503686,"score_spread":0.2597844600155132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}