{"id":"W4407634014","doi":"10.1101/2025.02.16.636315","title":"VIRUS-MVP: A framework for comprehensive surveillance of viral mutations and their functional impacts","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Simon Fraser University","funders":"Canadian Institutes of Health Research; Simon Fraser University; Michael Smith Health Research BC; Genome Canada","keywords":"Virology; Virus; Mutation; Biology; Business; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005345735,0.00264822,0.001783553,0.003606224,0.001216593,0.004687421,0.003510052,0.002501979,0.01216248],"category_scores_gemma":[0.005720708,0.0018109,0.003244342,0.001761667,0.001356794,0.003601354,0.00617552,0.003552033,0.008601671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001349854,"about_ca_system_score_gemma":0.003459694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006164114,"about_ca_topic_score_gemma":0.006752242,"domain_scores_codex":[0.9984092,0.0003747147,0.0002134553,0.0003878987,0.0004522425,0.0001624858],"domain_scores_gemma":[0.9984223,0.0005882143,0.0001453034,0.0004303632,0.0001887474,0.000225044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002090429,0.0005742012,0.01515547,0.005942591,0.001248171,0.003000939,0.002987564,0.08473256,0.06879321,0.2335585,0.2532915,0.3286249],"study_design_scores_gemma":[0.0003669967,0.0002065926,0.004102584,0.0008659503,0.0002272947,0.001318369,0.0003553655,0.2360876,0.02193696,0.2381387,0.4959531,0.0004404445],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.002760958,0.0007757753,0.8652639,0.0005053103,0.0001941143,0.0003664412,0.01369888,0.1123465,0.004088031],"genre_scores_gemma":[0.04654307,0.00261677,0.8725968,0.0006549751,0.0002040163,0.001616856,0.04936749,0.02140047,0.004999533],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.01216248,"threshold_uncertainty_score":0.04068756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03596086461780369,"score_gpt":0.3041373825702006,"score_spread":0.2681765179523969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}