{"id":"W4407638828","doi":"10.1021/acsmedchemlett.4c00545","title":"Synthesis and SAR Studies of Acyl-Thiourea Platinum(II) Complexes Yield Analogs with Dual-Stage Antiplasmodium Activity","year":2025,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"National Institute of Allergy and Infectious Diseases; South African Medical Research Council; Medical Research Council; National Institutes of Health; University of Cape Town; National Research Foundation","keywords":"Thiourea; Yield (engineering); Platinum; Chemistry; Stage (stratigraphy); Dual (grammatical number); Combinatorial chemistry; Organic chemistry; Biology; Materials science; Metallurgy; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001629777,0.0002447765,0.0002462291,0.0001110064,0.00009662887,0.0002443085,0.0003466987,0.0002265788,0.0009363653],"category_scores_gemma":[0.0002603845,0.0001450122,0.000114029,0.0001721484,0.0001430282,0.0001662828,0.0001555046,0.0003462744,0.0002801308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003198628,"about_ca_system_score_gemma":0.0001257003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004750306,"about_ca_topic_score_gemma":0.0008841004,"domain_scores_codex":[0.999917,0.00001689408,0.000009811589,0.00001563153,0.00002802185,0.00001260941],"domain_scores_gemma":[0.9999127,0.00001295091,0.00002422495,0.00001099884,0.00001925241,0.0000198438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002047704,0.00004265692,0.0001274403,0.00007703609,0.00000867536,0.00009417233,0.00004059482,0.0006455934,0.991985,0.0002341615,0.0001231113,0.006416828],"study_design_scores_gemma":[0.00007469166,0.00138229,0.0008165233,0.000005462155,0.0000240624,0.0004106463,0.00001389991,0.00169758,0.9909158,0.00003868863,0.00461191,0.000008471673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815049,0.002713744,0.01050698,0.0001317145,0.00003208373,0.0002329697,0.000371552,0.0001469824,0.004359101],"genre_scores_gemma":[0.9885656,0.001070173,0.007864574,0.00005007995,0.000009475698,0.00005194976,0.0003653586,0.00001785079,0.002005063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009363653,"threshold_uncertainty_score":0.003132463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04827858451732298,"score_gpt":0.2869168184580223,"score_spread":0.2386382339406993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}