{"id":"W4407640482","doi":"10.1099/acmi.0.000925.v3","title":"Immunogenicity of virus-like particle vaccine candidates against SARS-CoV-2 infection","year":2025,"lang":"en","type":"article","venue":"Access Microbiology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute on Deafness and Other Communication Disorders; Canadian Institutes of Health Research","keywords":"Immunogenicity; Virology; Virus; Vaccination; Antibody; Virus-like particle; Neutralizing antibody; Biology; Immunity; Immune system; Immunology; Gene; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002763796,0.0001826083,0.0004639408,0.0002397569,0.00009156203,0.00002570039,0.0002955097,0.0002047455,0.00002061386],"category_scores_gemma":[0.0001619204,0.0001552745,0.0001369663,0.0006606586,0.0001452961,0.000134589,0.0003253695,0.0002627619,0.00006937406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001173647,"about_ca_system_score_gemma":0.0002559571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003927178,"about_ca_topic_score_gemma":0.001887426,"domain_scores_codex":[0.9986019,0.0001162443,0.0004421794,0.0003656341,0.0000608346,0.0004132709],"domain_scores_gemma":[0.9990507,0.0001300353,0.0001152722,0.0004656875,0.0002225802,0.00001572539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005638502,0.000179447,0.2680563,0.00009119185,0.0001724047,0.000009097145,0.00003532519,3.744955e-7,0.726363,0.00005092946,0.002485979,0.001992115],"study_design_scores_gemma":[0.001865504,0.0001642628,0.02929513,0.00005903781,0.00006732439,0.00002226996,0.000008246853,0.0000557862,0.8900265,0.00008484629,0.07824103,0.0001101428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996263,0.001094868,0.0001411627,0.0003543222,0.0003361333,0.0003935045,0.00002652418,0.0000731927,0.001317349],"genre_scores_gemma":[0.9718825,0.00007778528,0.00002161282,0.02783692,0.00004938284,0.00003565202,0.00003307856,0.00001507856,0.00004800902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2387612,"threshold_uncertainty_score":0.633191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03236156713621019,"score_gpt":0.3691711603813096,"score_spread":0.3368095932450994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}