{"id":"W4407643520","doi":"10.1002/jor.26052","title":"Development of Reliable and High‐Throughput Human Biomimetic Cartilage and Bone Models to Explore Senescence and Personalized Osteoarthritis Treatment Options","year":2025,"lang":"en","type":"article","venue":"Journal of Orthopaedic Research®","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Delta; Dutch Arthritis Society; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; Leids Universitair Medisch Centrum; Arthritis Society","keywords":"Senescence; Cartilage; Downregulation and upregulation; Osteoarthritis; Organoid; Cell biology; Explant culture; Biology; Chondrocyte; Phenotype; In vitro; Medicine; Pathology; Gene; Anatomy; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001241461,0.0006975284,0.0007178594,0.0006981745,0.0002836515,0.0007795046,0.000632058,0.0008296694,0.001479031],"category_scores_gemma":[0.0005481933,0.0003520829,0.0008684096,0.0004080363,0.0003404055,0.0004114963,0.0004522883,0.001079121,0.0008173309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004187704,"about_ca_system_score_gemma":0.0006294352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001366909,"about_ca_topic_score_gemma":0.002934487,"domain_scores_codex":[0.9993037,0.0001381755,0.0000732411,0.000100102,0.0003160103,0.00006876521],"domain_scores_gemma":[0.9994845,0.00009406512,0.0001380017,0.00009455151,0.0001187975,0.00007006626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009030716,0.00008241581,0.000296859,0.0002387782,0.000023426,0.0000823203,0.00004215233,0.0009420826,0.9945989,0.0002244276,0.0002116903,0.003166548],"study_design_scores_gemma":[0.00004892556,0.001603221,0.005391147,0.00006991841,0.0001036524,0.0006576158,0.00008372456,0.00465602,0.9718938,0.0002993204,0.01515588,0.00003674577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7118248,0.02212074,0.2508782,0.0006093999,0.0004138919,0.001163946,0.006495228,0.001120323,0.005373542],"genre_scores_gemma":[0.8750027,0.01204146,0.09656871,0.0002633115,0.00007519708,0.001587902,0.006517525,0.0001623534,0.007780742],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001479031,"threshold_uncertainty_score":0.006565571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1036878179287523,"score_gpt":0.3649463847805517,"score_spread":0.2612585668517995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}