{"id":"W4407644311","doi":"10.3390/cells14040295","title":"Phenolic Compounds from Haskap Berries Have Structure, Combination, and Cell Line-Dependent Impacts on the Longevity-Associated Deacetylase Sirtuin 1","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Ministry of Agriculture - Saskatchewan","keywords":"Sirtuin 1; Caffeic acid; Chemistry; Biochemistry; Reactive oxygen species; Sirtuin; Antioxidant; Cell biology; Biology; Enzyme; Downregulation and upregulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001102118,0.0003249262,0.0003664769,0.0003082249,0.0001645794,0.0002905387,0.0000940941,0.0001724122,0.001560904],"category_scores_gemma":[0.0001615731,0.0001226628,0.0003824399,0.0002362072,0.0001611821,0.0002137116,0.000169909,0.0004183436,0.0002762951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001765971,"about_ca_system_score_gemma":0.0001679785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007678263,"about_ca_topic_score_gemma":0.001871805,"domain_scores_codex":[0.9999114,0.00001643087,0.000008935148,0.00002360514,0.00002011335,0.00001949917],"domain_scores_gemma":[0.9999144,0.00001709067,0.00001638501,0.00001205629,0.00002176685,0.00001832012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005261774,0.00004883093,0.000475544,0.0002111244,0.00003142328,0.00005209778,0.00002804946,0.00005702695,0.9951779,0.0000282358,0.00007953544,0.00328409],"study_design_scores_gemma":[0.00003832328,0.00161002,0.03335018,0.00002095317,0.000151303,0.0003205824,0.00007819224,0.0003381503,0.9591889,0.0000688013,0.004819966,0.00001455966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918194,0.003972487,0.001217693,0.0001292225,0.00006791807,0.00003310331,0.0009429595,0.00006426522,0.00175302],"genre_scores_gemma":[0.9927469,0.001901768,0.001333109,0.00008318752,0.00002410024,0.00002411544,0.001130134,0.00002466631,0.002731972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001560904,"threshold_uncertainty_score":0.005221725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120705348378528,"score_gpt":0.2526484581677827,"score_spread":0.2414414046839974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}