{"id":"W4407667435","doi":"10.1016/j.isci.2025.112015","title":"Signal transduction pathways controlling Ins2 gene activity and beta cell state transitions","year":2025,"lang":"en","type":"article","venue":"iScience","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health Research Institute; Vancouver Coastal Health","funders":"Breakthrough T1D Canada; Canadian Institutes of Health Research; University of British Columbia; Juvenile Diabetes Research Foundation Canada","keywords":"Signal transduction; Cell biology; Gene; Chemistry; Biology; Computational biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117473,0.0003793802,0.0001869434,0.0002643805,0.000187782,0.0006641007,0.0001267492,0.0002044796,0.0009534254],"category_scores_gemma":[0.0001004887,0.0001462981,0.0001877906,0.0002184861,0.000259313,0.0003932189,0.0002089349,0.0003977271,0.0002175619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003125896,"about_ca_system_score_gemma":0.0001792478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003421158,"about_ca_topic_score_gemma":0.0005901878,"domain_scores_codex":[0.999923,0.000007948504,0.000004163068,0.00002707592,0.00002096108,0.00001678633],"domain_scores_gemma":[0.9999224,0.00001061237,0.00002910167,0.000005876554,0.00001039679,0.0000216948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005614218,0.000004438085,0.0003612077,0.000009830691,0.000002429223,0.0000180172,0.00001039756,0.0000248206,0.999029,0.00005289307,0.00001033958,0.0004205896],"study_design_scores_gemma":[0.000009036776,0.00007073265,0.03474863,0.000005050015,0.00001770591,0.000148977,0.0001098494,0.001142178,0.9623201,0.0001882892,0.001231538,0.00000793024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932685,0.001046514,0.004050946,0.00007296239,0.00001504301,0.00001232562,0.0004701493,0.00008027723,0.0009831205],"genre_scores_gemma":[0.9943112,0.001081833,0.00257697,0.00006417404,0.00001069818,0.00002355926,0.0005907174,0.00003130801,0.001309476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009534254,"threshold_uncertainty_score":0.003189564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633384883965207,"score_gpt":0.2385443280968921,"score_spread":0.22221047925724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}