{"id":"W4407669741","doi":"10.1002/pbc.31595","title":"MEK Inhibition With Trametinib for the treatment of MAP2K1‐Mutated Rosai–Dorfman–Destombes Disease Arising from the Nasopharynx in a Paediatric Patient","year":2025,"lang":"en","type":"letter","venue":"Pediatric Blood & Cancer","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Trametinib; Medicine; Rosai–Dorfman disease; Disease; MEK inhibitor; Oncology; Cancer research; Internal medicine; Genetics; MAPK/ERK pathway; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002378427,0.000333932,0.000500671,0.0003269631,0.001042877,0.0007503,0.0004922518,0.003777602,0.001958447],"category_scores_gemma":[0.001507616,0.0002110075,0.0005019407,0.0003347946,0.0006368582,0.000595173,0.0003575871,0.004142052,0.0009806359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001862338,"about_ca_system_score_gemma":0.001027926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002721785,"about_ca_topic_score_gemma":0.006862296,"domain_scores_codex":[0.9997266,0.00004874536,0.0000307922,0.00003976963,0.00006717705,0.00008688292],"domain_scores_gemma":[0.999524,0.0001678555,0.00004536594,0.00001812801,0.00004418995,0.0002004004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.000469281,0.0001742757,0.01585512,0.0001916967,0.00007044167,0.7606328,0.0003521998,0.001450977,0.004815931,0.005828009,0.1675137,0.04264561],"study_design_scores_gemma":[0.0002584139,0.0004617155,0.01463669,0.00025473,0.00007081345,0.8655058,0.0003312607,0.003242137,0.003163609,0.005808257,0.106212,0.00005468795],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.3541404,0.02333574,0.003319219,0.5246248,0.01598237,0.0002262946,0.001177902,0.0003452266,0.07684807],"genre_scores_gemma":[0.8811199,0.008824981,0.002659639,0.08059777,0.01003694,0.00009238724,0.0004660171,0.00008125504,0.01612108],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003777602,"threshold_uncertainty_score":0.01351225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01295494596158855,"score_gpt":0.2559682468103735,"score_spread":0.2430133008487849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}