{"id":"W4407669741","doi":"10.1002/pbc.31595","title":"MEK Inhibition With Trametinib for the treatment of MAP2K1‐Mutated Rosai–Dorfman–Destombes Disease Arising from the Nasopharynx in a Paediatric Patient","year":2025,"lang":"en","type":"letter","venue":"Pediatric Blood & Cancer","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Trametinib; Medicine; Rosai–Dorfman disease; Disease; MEK inhibitor; Oncology; Cancer research; Internal medicine; Genetics; MAPK/ERK pathway; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007946212,0.0005381468,0.0007839496,0.0002604695,0.0001567382,0.0000395175,0.0001378212,0.00026707,0.00007243003],"category_scores_gemma":[0.00007150886,0.000284313,0.0003507279,0.0007877259,0.0001051164,0.00004654414,0.00002444742,0.0004479943,0.000004234464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003261261,"about_ca_system_score_gemma":0.001111053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003688358,"about_ca_topic_score_gemma":0.0003902427,"domain_scores_codex":[0.9975977,0.000103423,0.0006263978,0.0006554299,0.0005487556,0.0004683114],"domain_scores_gemma":[0.9975651,0.001142363,0.0004536391,0.0005737179,0.000168633,0.00009654975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005091211,0.00855244,0.2800615,0.002908437,0.005202042,0.002458117,0.006083696,0.0007210426,0.000005044126,0.00001381603,0.6244195,0.06448318],"study_design_scores_gemma":[0.08872889,0.00990374,0.1270037,0.002943907,0.1433758,0.00003314434,0.0008007261,0.0009500458,0.0003204927,0.001123828,0.6223901,0.002425651],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6792514,0.1157245,0.00007029632,0.1899856,0.0009218484,0.007701017,0.006082103,0.00008996733,0.0001732165],"genre_scores_gemma":[0.7570235,0.07333881,0.0007887382,0.1368578,0.01046515,0.0114699,0.007609175,0.0003413997,0.002105603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1530578,"threshold_uncertainty_score":0.9999609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01295494596158855,"score_gpt":0.2559682468103735,"score_spread":0.2430133008487849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}