{"id":"W4407676836","doi":"10.1111/apt.70048","title":"Letter: Lubiprostone—A Novel Therapeutic Avenue for Gastrointestinal Complications in <scp>MASLD</scp>. Authors' Reply","year":2025,"lang":"en","type":"letter","venue":"Alimentary Pharmacology & Therapeutics","topic":"Gastroesophageal reflux and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Lubiprostone; Medicine; Gastroenterology; Internal medicine; Constipation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001963174,0.000750427,0.001661948,0.0007509542,0.001357257,0.00204144,0.001954191,0.02308793,0.003794256],"category_scores_gemma":[0.01825464,0.0004820888,0.00117527,0.0004910598,0.001743224,0.003411271,0.0008861176,0.02051837,0.002802487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00175881,"about_ca_system_score_gemma":0.001571999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001483481,"about_ca_topic_score_gemma":0.001339626,"domain_scores_codex":[0.9988146,0.0003951164,0.0001981381,0.0001971433,0.0002528573,0.0001422023],"domain_scores_gemma":[0.9955482,0.002395981,0.0003628487,0.0001412656,0.0009782258,0.000573381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002577342,0.00006282255,0.001534865,0.0003073034,0.00005488643,0.01074316,0.0002008306,0.0001302307,0.0003592508,0.001164712,0.9694933,0.01569084],"study_design_scores_gemma":[0.0003370921,0.0002885937,0.00339701,0.0008052811,0.0001308103,0.05671069,0.000878641,0.00135517,0.001117455,0.007209918,0.9275119,0.0002574076],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001942006,0.008294015,0.0003381988,0.9222524,0.0657327,0.000031528,0.0001465771,0.0001301986,0.001132412],"genre_scores_gemma":[0.01477179,0.005950497,0.0007182846,0.8384119,0.1362329,0.00007744168,0.00007714197,0.00005097727,0.00370912],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02308793,"threshold_uncertainty_score":0.01276118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04994515309479444,"score_gpt":0.3491100140670978,"score_spread":0.2991648609723033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}