{"id":"W4407678310","doi":"10.1200/jco.2025.43.5_suppl.440","title":"KEYMAKER-U03 Substudy 03B: Pembrolizumab (pembro) and targeted therapy combinations for advanced clear cell renal cell carcinoma (ccRCC).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Pembrolizumab; Renal cell carcinoma; Clear cell renal cell carcinoma; Oncology; Internal medicine; Cancer research; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007273299,0.0009104797,0.002323607,0.0006749874,0.001022318,0.001458533,0.0014097,0.001670651,0.007372393],"category_scores_gemma":[0.003584076,0.0005403458,0.001740834,0.001601816,0.0005746118,0.001089751,0.000807052,0.001883075,0.002117962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001852273,"about_ca_system_score_gemma":0.002308335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003733854,"about_ca_topic_score_gemma":0.02370329,"domain_scores_codex":[0.9960287,0.002671612,0.000325924,0.0002986973,0.0003430938,0.0003320009],"domain_scores_gemma":[0.9974706,0.000574263,0.0008578407,0.0002086442,0.0002613882,0.0006273278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5668153,0.01613589,0.09963381,0.008002273,0.01232493,0.000480295,0.000445291,0.002051717,0.02080778,0.0008090715,0.08515004,0.1873437],"study_design_scores_gemma":[0.4726174,0.2230412,0.1970128,0.001060299,0.01425327,0.00192767,0.0003232533,0.001642012,0.008001191,0.0007514195,0.07925815,0.0001112901],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8514963,0.04815609,0.001802108,0.002650097,0.000715018,0.02262164,0.05058763,0.0004125959,0.02155853],"genre_scores_gemma":[0.9305969,0.009176688,0.003964847,0.004699405,0.0006577503,0.01598276,0.0311852,0.0001143854,0.003622125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007372393,"threshold_uncertainty_score":0.03846538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07810510800763588,"score_gpt":0.4207072258296449,"score_spread":0.3426021178220091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}