{"id":"W4407678390","doi":"10.1200/jco.2025.43.5_suppl.479","title":"Cabozantinib real-world effectiveness in the second-line setting of metastatic renal cell carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; McMaster University; University of Calgary","funders":"","keywords":"Cabozantinib; Medicine; Renal cell carcinoma; Oncology; Internal medicine; Urology; Database","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003944161,0.0003872291,0.001002266,0.001022671,0.0002256374,0.001249755,0.0007110118,0.0004934662,0.00171043],"category_scores_gemma":[0.00582966,0.0001919182,0.001583929,0.00207822,0.0002049551,0.0007223606,0.0006679199,0.000518736,0.0004058393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001160768,"about_ca_system_score_gemma":0.0008682362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005371455,"about_ca_topic_score_gemma":0.009964261,"domain_scores_codex":[0.9968811,0.001290452,0.0004715592,0.0005497605,0.0006426301,0.0001644135],"domain_scores_gemma":[0.9905867,0.002323969,0.005277363,0.0005833482,0.0005649515,0.0006637307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03082348,0.0004715413,0.9397575,0.0008531243,0.004577809,0.0001256119,0.0001127139,0.001316834,0.0004395626,0.0001320075,0.006390307,0.01499952],"study_design_scores_gemma":[0.005527224,0.002290131,0.9781169,0.0001807621,0.003104828,0.0006647829,0.0001644461,0.003866618,0.0006082565,0.00009222257,0.005337398,0.00004660674],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9436069,0.006362319,0.0002421148,0.0003135529,0.00002369933,0.0001910442,0.04774122,0.00003024635,0.001488864],"genre_scores_gemma":[0.9604986,0.0009809855,0.0003205762,0.0002054981,0.00004554561,0.0001252596,0.03757183,0.00001059945,0.0002409698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005371455,"threshold_uncertainty_score":0.02085894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09868426204672401,"score_gpt":0.4182768572731753,"score_spread":0.3195925952264512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}