{"id":"W4407678786","doi":"10.1021/acs.analchem.4c06414","title":"Bidirectionally Favorable Platform: A Dual-Targeting Probe-Encoded Maple Leaf-Type Fluorescent Lateral Flow Immunoassay for Multiple Biomarker Detection","year":2025,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"Fundamental Research Funds for the Central Universities; State Key Laboratory of Natural Medicines","keywords":"Detection limit; Chemistry; Nanoclusters; Chromatography; Fluorescence; Nanotechnology; Materials science; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005165534,0.0009002314,0.0003323653,0.00057,0.000219575,0.0005613485,0.0006140809,0.001187594,0.0009949285],"category_scores_gemma":[0.0006169707,0.0003794949,0.0003455774,0.0002140018,0.0003410711,0.0007824714,0.0006949019,0.001007617,0.001019358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004463764,"about_ca_system_score_gemma":0.0003754751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004207134,"about_ca_topic_score_gemma":0.0006302194,"domain_scores_codex":[0.9995456,0.00007348758,0.00001825314,0.000137359,0.0001575518,0.00006776452],"domain_scores_gemma":[0.9997618,0.00004979706,0.00006916704,0.00001822594,0.00006009663,0.00004099806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005950392,0.0000345151,0.0001126731,0.000066383,0.000006704835,0.00007659912,0.00002764928,0.0001511312,0.9911493,0.0004991052,0.0002687666,0.007547632],"study_design_scores_gemma":[0.00001811023,0.0002180428,0.0003096865,0.000006993437,0.00001465846,0.0002702229,0.00001704969,0.004522857,0.9896355,0.0001627448,0.004788992,0.00003512694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4750708,0.0041531,0.506341,0.001277111,0.0003996935,0.0007130195,0.000824254,0.00354467,0.007676242],"genre_scores_gemma":[0.7145118,0.001581304,0.274349,0.0009301197,0.0001091689,0.0006790519,0.000582102,0.0001006906,0.007156676],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001187594,"threshold_uncertainty_score":0.003328323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01279241913422323,"score_gpt":0.275287330206665,"score_spread":0.2624949110724418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}