{"id":"W4407695496","doi":"10.7554/elife.97682.3.sa0","title":"eLife Assessment: Multiplexed assays of human disease-relevant mutations reveal UTR dinucleotide composition as a major determinant of RNA stability","year":2025,"lang":"en","type":"peer-review","venue":"","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"RNA; Genetics; Composition (language); Computational biology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002408089,0.0006576166,0.0007338792,0.001527834,0.0007021613,0.001470412,0.0007886607,0.001056967,0.007681364],"category_scores_gemma":[0.00386263,0.0005441948,0.0003172516,0.0008917259,0.0005271962,0.0007265602,0.0009794114,0.00102975,0.005097987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008152592,"about_ca_system_score_gemma":0.0009346272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001714341,"about_ca_topic_score_gemma":0.006662112,"domain_scores_codex":[0.9974323,0.0003248396,0.0001322497,0.0006105484,0.001232734,0.0002673735],"domain_scores_gemma":[0.9978052,0.0004793266,0.0003329428,0.0002087489,0.0009842489,0.0001895152],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004393307,0.00006858729,0.007151231,0.0002212189,0.0000672938,0.0002655923,0.000233204,0.0003766876,0.9099956,0.001379769,0.008070206,0.07173135],"study_design_scores_gemma":[0.00001933256,0.00009098555,0.01310789,0.00002355833,0.00003921182,0.0003800123,0.00007114001,0.00201879,0.9577274,0.0004306919,0.02606801,0.00002301717],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.6589842,0.009691151,0.2526094,0.003637878,0.001837466,0.0007655121,0.01362922,0.008965744,0.04987949],"genre_scores_gemma":[0.6530464,0.003606003,0.2381359,0.001370092,0.0002618473,0.0005023507,0.00810053,0.001345325,0.09363145],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.9975919,"threshold_uncertainty_score":0.02569675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02478718453488459,"score_gpt":0.3514816082184114,"score_spread":0.3266944236835268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}