{"id":"W4407698783","doi":"10.1200/jco.2025.43.5_suppl.tps898","title":"A phase 2/3 study of bicycle toxin conjugate zelenectide pevedotin (BT8009) targeting Nectin-4 in patients with locally advanced or metastatic urothelial cancer (la/mUC) (Duravelo-2).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Urothelial cancer; Medicine; Conjugate; Cancer; Cancer research; Oncology; Internal medicine; Bladder cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001525186,0.001784444,0.00159851,0.0003940171,0.000441425,0.001152713,0.0009944215,0.001608653,0.006633341],"category_scores_gemma":[0.0009098584,0.0006088373,0.001261687,0.0003727279,0.0008798506,0.001097076,0.0004970126,0.003389355,0.001635407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00126659,"about_ca_system_score_gemma":0.001939883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00127142,"about_ca_topic_score_gemma":0.003687837,"domain_scores_codex":[0.9996388,0.0001448296,0.00001404814,0.00007221755,0.00003192439,0.00009813019],"domain_scores_gemma":[0.9993905,0.00006799292,0.000111972,0.00004963115,0.00004242866,0.0003374528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6974106,0.1160042,0.008001244,0.001486096,0.001252295,0.0005360831,0.0005346076,0.003563409,0.06549779,0.0005003253,0.008269962,0.09694339],"study_design_scores_gemma":[0.5332924,0.4460427,0.009737669,0.00005004736,0.0004102379,0.0004165317,0.0001101494,0.001193868,0.003490544,0.0003358328,0.004885392,0.00003462519],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804864,0.002018635,0.001210474,0.0008062699,0.0002012151,0.008788818,0.003174718,0.0002028519,0.003110557],"genre_scores_gemma":[0.9698586,0.001964835,0.003378182,0.002038716,0.0001977753,0.01059947,0.006018351,0.00009200124,0.00585195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006633341,"threshold_uncertainty_score":0.02219075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05430610272365684,"score_gpt":0.4685326335031526,"score_spread":0.4142265307794958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}